{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["30(10)"],"submitter":["Lin AY"],"pubmed_abstract":["Inclusion body myositis is the most commonly acquired myopathy after the age of 45. The slowly progressive and heterogeneous disorder is a challenge for measuring clinical trial efficacy. One current method for measuring progression utilizes the Inclusion Body Myositis-Functional Rating Scale. We have found that the upper extremity domain scores in the Inclusion Body Myositis-Functional Rating Scale do not consistently change until there is extreme loss of grip and finger flexor strength. Therefore, we performed a cross-sectional observational study of 83 inclusion body myositis patients and 38 controls recruited at the 2019 Annual Patient Conference of The Myositis Association. We evaluated new Inclusion Body Myositis Patient-Reported Outcome measures for upper extremity function modified from the NIH Patient-Reported Outcomes Measurement Information System as well as pinch and grip strength. We found that Patient-Reported Outcome measures hand-function have a higher correlation with pinch and grip strength than the Inclusion Body Myositis-Functional Rating Scale."],"journal":["Neuromuscular disorders : NMD"],"pagination":["807-814"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9756909"],"repository":["biostudies-literature"],"pubmed_title":["Optimizing hand-function patient outcome measures for inclusion body myositis."],"pmcid":["PMC9756909"],"pubmed_authors":["Weihl CC","Seiffert M","Wang LH","Faino AV","Lin AY","Siener CS"],"additional_accession":[]},"is_claimable":false,"name":"Optimizing hand-function patient outcome measures for inclusion body myositis.","description":"Inclusion body myositis is the most commonly acquired myopathy after the age of 45. The slowly progressive and heterogeneous disorder is a challenge for measuring clinical trial efficacy. One current method for measuring progression utilizes the Inclusion Body Myositis-Functional Rating Scale. We have found that the upper extremity domain scores in the Inclusion Body Myositis-Functional Rating Scale do not consistently change until there is extreme loss of grip and finger flexor strength. Therefore, we performed a cross-sectional observational study of 83 inclusion body myositis patients and 38 controls recruited at the 2019 Annual Patient Conference of The Myositis Association. We evaluated new Inclusion Body Myositis Patient-Reported Outcome measures for upper extremity function modified from the NIH Patient-Reported Outcomes Measurement Information System as well as pinch and grip strength. We found that Patient-Reported Outcome measures hand-function have a higher correlation with pinch and grip strength than the Inclusion Body Myositis-Functional Rating Scale.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-05-29T16:30:11.867Z","creation":"2025-05-29T16:30:11.867Z"},"accession":"S-EPMC9756909","cross_references":{"pubmed":["32928647"],"doi":["10.1016/j.nmd.2020.08.358"]}}