{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Trivedi S"],"funding":["Department of Biology of Masaryk University, Faculty of Medicine","Czech Science Foundation"],"pubmed_abstract":["Meiotic chromosome segregation relies on programmed DNA double-strand break induction. These are in turn repaired by homologous recombination, generating physical attachments between the parental chromosomes called crossovers. A subset of breaks yields recombinant outcomes, while crossover-independent mechanisms repair the majority of lesions. The balance between different repair pathways is crucial to ensure genome integrity. We show that Caenorhabditis elegans BRC-1/BRCA1-BRD-1/BARD1 and PARG-1/PARG form a complex in vivo, essential for accurate DNA repair in the germline. Simultaneous depletion of BRC-1 and PARG-1 causes synthetic lethality due to reduced crossover formation and impaired break repair, evidenced by hindered RPA-1 removal and presence of aberrant chromatin bodies in diaki"],"journal":["Nucleic acids research"],"pagination":["gkac1153"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9757042"],"repository":["biostudies-literature"],"pubmed_title":["PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis."],"pmcid":["PMC9757042"],"funding_grant_id":["GA20-08819S"],"pubmed_authors":["Trivedi S","Blazickova J","Silva N"],"additional_accession":[]},"is_claimable":false,"name":"PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.","description":"Meiotic chromosome segregation relies on programmed DNA double-strand break induction. These are in turn repaired by homologous recombination, generating physical attachments between the parental chromosomes called crossovers. A subset of breaks yields recombinant outcomes, while crossover-independent mechanisms repair the majority of lesions. The balance between different repair pathways is crucial to ensure genome integrity. We show that Caenorhabditis elegans BRC-1/BRCA1-BRD-1/BARD1 and PARG-1/PARG form a complex in vivo, essential for accurate DNA repair in the germline. Simultaneous depletion of BRC-1 and PARG-1 causes synthetic lethality due to reduced crossover formation and impaired break repair, evidenced by hindered RPA-1 removal and presence of aberrant chromatin bodies in diaki","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T08:56:00.818Z","creation":"2025-04-04T08:56:00.818Z"},"accession":"S-EPMC9757042","cross_references":{"pubmed":["36478097"],"doi":["10.1093/nar/gkac1153"]}}