{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gomez-Linan C"],"funding":["Spanish Ministry of Science and Innovation","Spanish National Research Council","La Caixa Foundation-Health Research 2020 Call"],"pagination":["12251-12265"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9757043"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(21)"],"pubmed_abstract":["In-depth analysis of the transcriptomes of several model organisms has revealed that genomes are pervasively transcribed, giving rise to an abundance of non-canonical and mainly antisense RNA polymerase II-derived transcripts that are produced from almost any genomic context. Pervasive RNAs are degraded by surveillance mechanisms, but the repertoire of proteins that control the fate of these non-productive transcripts is still incomplete. Trypanosomes are single-celled eukaryotes that show constitutive RNA polymerase II transcription and in which initiation and termination of transcription occur at a limited number of sites per chromosome. It is not known whether pervasive transcription exists in organisms with unregulated RNA polymerase II activity, and which factors could be involved in "],"journal":["Nucleic acids research"],"pubmed_title":["The RNA-binding protein RBP33 dampens non-productive transcription in trypanosomes."],"pmcid":["PMC9757043"],"funding_grant_id":["201920E114","PID2019-111109RB-I00","HR20-00635"],"pubmed_authors":["Gomez-Linan C","Ceballos-Perez G","Fernandez-Moya SM","Estevez AM","Gomez-Diaz E"],"additional_accession":[]},"is_claimable":false,"name":"The RNA-binding protein RBP33 dampens non-productive transcription in trypanosomes.","description":"In-depth analysis of the transcriptomes of several model organisms has revealed that genomes are pervasively transcribed, giving rise to an abundance of non-canonical and mainly antisense RNA polymerase II-derived transcripts that are produced from almost any genomic context. Pervasive RNAs are degraded by surveillance mechanisms, but the repertoire of proteins that control the fate of these non-productive transcripts is still incomplete. Trypanosomes are single-celled eukaryotes that show constitutive RNA polymerase II transcription and in which initiation and termination of transcription occur at a limited number of sites per chromosome. It is not known whether pervasive transcription exists in organisms with unregulated RNA polymerase II activity, and which factors could be involved in ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Nov","modification":"2026-05-08T03:15:02.98Z","creation":"2025-06-01T01:56:23.003Z"},"accession":"S-EPMC9757043","cross_references":{"pubmed":["36454008"],"doi":["10.1093/nar/gkac1123"]}}