biostudies-literatureLin HNIDDK NIH HHSHenry Samueli School of Engineering and Applied Science, University of California, Los AngelesNational Institutes of Health4267-4275https://www.ebi.ac.uk/biostudies/studies/S-EPMC9757655biostudies-literatureUnknown22(22)Advancements in wearable bioanalytical microsystems have enabled diurnal and (semi)continuous monitoring of physiologically-relevant indices that are accessible through probing sweat. To deliver an undistorted and physiologically-meaningful interpretation of these readings, tracking the sweat secretion rate is essential, because it allows for calibrating the biomarker readings against variations in sweat secretion and inferring the body's hydration/electrolyte homeostasis status. To realize an autonomous wearable solution with intrinsically high signal-to-noise ratio sweat rate sensing capabilities, here, we devise a digitized microbubble detection mechanism-delivered by a hybrid microfluidic/electronic system with a compact footprint. This mechanism is based on the intermittent generationLab on a chipAutonomous wearable sweat rate monitoring based on digitized microbubble detection.PMC9757655R21 DK128711R21DK128711-01Lin SLin HYu WMilla CSankararaman SEmaminejad SAthavan HWang YYeung CSuarez JEDfalseAutonomous wearable sweat rate monitoring based on digitized microbubble detection.Advancements in wearable bioanalytical microsystems have enabled diurnal and (semi)continuous monitoring of physiologically-relevant indices that are accessible through probing sweat. To deliver an undistorted and physiologically-meaningful interpretation of these readings, tracking the sweat secretion rate is essential, because it allows for calibrating the biomarker readings against variations in sweat secretion and inferring the body's hydration/electrolyte homeostasis status. To realize an autonomous wearable solution with intrinsically high signal-to-noise ratio sweat rate sensing capabilities, here, we devise a digitized microbubble detection mechanism-delivered by a hybrid microfluidic/electronic system with a compact footprint. This mechanism is based on the intermittent generation2022-01-01T00:00:00Z2022 Nov2025-04-04T13:09:35.029Z2025-04-04T13:09:35.029ZS-EPMC97576553626864210.1039/d2lc00670g