{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Han RT"],"funding":["National Institute of Neurological Disorders and Stroke","Helen Diller Family Comprehensive Cancer Center Laboratory","Pew Charitable Trusts","NIMH NIH HHS","Brain and Behavior Research Foundation","Burroughs Welcome Fund","National Institutes of Health","Department of Defense","Gladstone Institutes","NCI NIH HHS","NINDS NIH HHS","National Institute of Mental Health","National Science Foundation"],"pagination":["e20220605"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9757845"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["220(2)"],"pubmed_abstract":["Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here, we characterized the regulatory program downstream of interleukin-33 (IL-33), a cytokine that promotes microglial synapse remodeling. Exposing the developing brain to a supraphysiological dose of IL-33 altered the microglial enhancer landscape and increased binding of stimulus-dependent transcription factors including AP-1/FOS. This induced a gene expression program enriched for the expression of pattern recognition receptors, including the scavenger receptor MARCO. CNS-specific deletion of IL-33 led to increased excitatory/inhibitory synaptic balance, spontaneous abs"],"journal":["The Journal of experimental medicine"],"pubmed_title":["Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice."],"pmcid":["PMC9757845"],"funding_grant_id":["RR18928","NS096170","P30 CA082103","R01MH119349","DP2 MH116507","R01 MH119349","R01 NS096369","P30CA082103","NS111819","DP2MH116507","R01 NS096369-01","EP150038","R01MH125000","1608236"],"pubmed_authors":["Schlachetzki JCM","Cho FS","Molofsky AV","Ahn E","Han RT","Kim DK","Nakao-Inoue H","Glass CK","Paz JT","Barron JJ","Molofsky AB","Vainchtein ID","Dorman LC"],"additional_accession":[]},"is_claimable":false,"name":"Microglial pattern recognition via IL-33 promotes synaptic refinement in developing corticothalamic circuits in mice.","description":"Microglia are critical regulators of brain development that engulf synaptic proteins during postnatal synapse remodeling. However, the mechanisms through which microglia sense the brain environment are not well defined. Here, we characterized the regulatory program downstream of interleukin-33 (IL-33), a cytokine that promotes microglial synapse remodeling. Exposing the developing brain to a supraphysiological dose of IL-33 altered the microglial enhancer landscape and increased binding of stimulus-dependent transcription factors including AP-1/FOS. This induced a gene expression program enriched for the expression of pattern recognition receptors, including the scavenger receptor MARCO. CNS-specific deletion of IL-33 led to increased excitatory/inhibitory synaptic balance, spontaneous abs","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Feb","modification":"2025-04-21T16:19:24.147Z","creation":"2025-04-21T16:19:24.147Z"},"accession":"S-EPMC9757845","cross_references":{"pubmed":["36520518"],"doi":["10.1084/jem.20220605"]}}