{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Clerkin KJ"],"funding":["NHLBI NIH HHS"],"pagination":["1617-1628"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9758655"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["80(17)"],"pubmed_abstract":["<h4>Background</h4>Cardiac allograft vasculopathy (CAV) causes impaired blood flow in both epicardial coronary arteries and the microvasculature. A leading cause of post-transplant mortality, CAV affects 50% of heart transplant recipients within 10 years of heart transplant.<h4>Objectives</h4>This analysis examined the outcomes of heart transplant recipients with reduced myocardial blood flow reserve (MBFR) and microvascular CAV detected by <sup>13</sup>N-ammonia positron emission tomography (PET) myocardial perfusion imaging.<h4>Methods</h4>A total of 181 heart transplant recipients who underwent PET to assess for CAV were included with a median follow-up of 4.7 years. Patients were classified into 2 groups according to the total MBFR: >2.0 and ≤2.0. Microvascular CAV was defined as no ep"],"journal":["Journal of the American College of Cardiology"],"pubmed_title":["Noninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events."],"pmcid":["PMC9758655"],"funding_grant_id":["K23 HL148528","K08 HL146964"],"pubmed_authors":["Clerkin KJ","Jain R","Castillo M","Chernovolenko M","Johnson LL","Lam EY","Topkara VK","Colombo PC","DeFilippis E","Farr MA","Uriel N","Restaino S","Latif F","Einstein AJ","Zorn E","Yuzefpolskaya M","Sayer G","Takeda K"],"additional_accession":[]},"is_claimable":false,"name":"Noninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events.","description":"<h4>Background</h4>Cardiac allograft vasculopathy (CAV) causes impaired blood flow in both epicardial coronary arteries and the microvasculature. A leading cause of post-transplant mortality, CAV affects 50% of heart transplant recipients within 10 years of heart transplant.<h4>Objectives</h4>This analysis examined the outcomes of heart transplant recipients with reduced myocardial blood flow reserve (MBFR) and microvascular CAV detected by <sup>13</sup>N-ammonia positron emission tomography (PET) myocardial perfusion imaging.<h4>Methods</h4>A total of 181 heart transplant recipients who underwent PET to assess for CAV were included with a median follow-up of 4.7 years. Patients were classified into 2 groups according to the total MBFR: >2.0 and ≤2.0. Microvascular CAV was defined as no ep","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Oct","modification":"2025-04-22T11:58:22.02Z","creation":"2025-04-06T00:07:13.667Z"},"accession":"S-EPMC9758655","cross_references":{"pubmed":["36265957"],"doi":["10.1016/j.jacc.2022.08.751"]}}