biostudies-literatureClerkin KJNHLBI NIH HHS1617-1628https://www.ebi.ac.uk/biostudies/studies/S-EPMC9758655biostudies-literatureUnknown80(17)<h4>Background</h4>Cardiac allograft vasculopathy (CAV) causes impaired blood flow in both epicardial coronary arteries and the microvasculature. A leading cause of post-transplant mortality, CAV affects 50% of heart transplant recipients within 10 years of heart transplant.<h4>Objectives</h4>This analysis examined the outcomes of heart transplant recipients with reduced myocardial blood flow reserve (MBFR) and microvascular CAV detected by ¹³N-ammonia positron emission tomography (PET) myocardial perfusion imaging.<h4>Methods</h4>A total of 181 heart transplant recipients who underwent PET to assess for CAV were included with a median follow-up of 4.7 years. Patients were classified into 2 groups according to the total MBFR: >2.0 and ≤2.0. Microvascular CAV was defined as no epJournal of the American College of CardiologyNoninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events.PMC9758655K23 HL148528K08 HL146964Clerkin KJJain RCastillo MChernovolenko MJohnson LLLam EYTopkara VKColombo PCDeFilippis EFarr MAUriel NRestaino SLatif FEinstein AJZorn EYuzefpolskaya MSayer GTakeda KfalseNoninvasive Physiologic Assessment of Cardiac Allograft Vasculopathy Is Prognostic for Post-Transplant Events.<h4>Background</h4>Cardiac allograft vasculopathy (CAV) causes impaired blood flow in both epicardial coronary arteries and the microvasculature. A leading cause of post-transplant mortality, CAV affects 50% of heart transplant recipients within 10 years of heart transplant.<h4>Objectives</h4>This analysis examined the outcomes of heart transplant recipients with reduced myocardial blood flow reserve (MBFR) and microvascular CAV detected by ¹³N-ammonia positron emission tomography (PET) myocardial perfusion imaging.<h4>Methods</h4>A total of 181 heart transplant recipients who underwent PET to assess for CAV were included with a median follow-up of 4.7 years. Patients were classified into 2 groups according to the total MBFR: >2.0 and ≤2.0. Microvascular CAV was defined as no ep2022-01-01T00:00:00Z2022 Oct2025-04-22T11:58:22.02Z2025-04-06T00:07:13.667ZS-EPMC97586553626595710.1016/j.jacc.2022.08.751