{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mulick AR"],"funding":["British Heart Foundation","Medical Research Council","Wellcome Trust"],"pagination":["21866"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9760185"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Eczema and asthma are allergic diseases and two of the commonest chronic conditions in high-income countries. Their co-existence with other allergic conditions is common, but little research exists on wider multimorbidity with these conditions. We set out to identify and compare clusters of multimorbidity in people with eczema or asthma and people without. Using routinely-collected primary care data from the U.K. Clinical Research Practice Datalink GOLD, we identified adults ever having eczema (or asthma), and comparison groups never having eczema (or asthma). We derived clusters of multimorbidity from hierarchical cluster analysis of Jaccard distances between pairs of diagnostic categories estimated from mixed-effects logistic regressions. We analysed 434,422 individuals with eczema (58% "],"journal":["Scientific reports"],"pubmed_title":["Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis."],"pmcid":["PMC9760185"],"funding_grant_id":["MR/V005146/1","205039/Z/16/Z","HDR-9006","MR/S027750/1"],"pubmed_authors":["Matthewman J","Lyons RA","Langan SM","Mulick AR","McAllister DA","Henderson AD","Prieto-Merino D","Mansfield KE","Sheikh A","Nitsch D","Quint JK"],"additional_accession":[]},"is_claimable":false,"name":"Novel multimorbidity clusters in people with eczema and asthma: a population-based cluster analysis.","description":"Eczema and asthma are allergic diseases and two of the commonest chronic conditions in high-income countries. Their co-existence with other allergic conditions is common, but little research exists on wider multimorbidity with these conditions. We set out to identify and compare clusters of multimorbidity in people with eczema or asthma and people without. Using routinely-collected primary care data from the U.K. Clinical Research Practice Datalink GOLD, we identified adults ever having eczema (or asthma), and comparison groups never having eczema (or asthma). We derived clusters of multimorbidity from hierarchical cluster analysis of Jaccard distances between pairs of diagnostic categories estimated from mixed-effects logistic regressions. We analysed 434,422 individuals with eczema (58% ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T13:46:41.721Z","creation":"2025-04-04T13:46:41.721Z"},"accession":"S-EPMC9760185","cross_references":{"pubmed":["36529816"],"doi":["10.1038/s41598-022-26357-x"]}}