biostudies-literatureUnknown12(55)Wang XYDescribed here is a unprecedented organophotoredox/manganese dual catalyzed proton reduction and its application for semi-reduction of alkynes. The catalytic active pre-catalyst [Mn-1] can be feasibly be prepared on gram-scale from Mn(acac)2·2H2O in air. This dual catalytic protocol features noble-metal-free catalysts, simple ligand, and mild conditions. Besides, a unique ortho-halogen and -hydroxyl effect was observed to achieve high Z-stereoselectivity.RSC advances36138-36141https://www.ebi.ac.uk/biostudies/studies/S-EPMC9761695biostudies-literatureVisible-light-driven proton reduction for semi-hydrogenation of alkynes via organophotoredox/manganese dual catalysis.PMC9761695Wang MZhou ZZSong XRZhou YTian WFHe YQWang XYLi NXiao QfalseVisible-light-driven proton reduction for semi-hydrogenation of alkynes via organophotoredox/manganese dual catalysis.Described here is a unprecedented organophotoredox/manganese dual catalyzed proton reduction and its application for semi-reduction of alkynes. The catalytic active pre-catalyst [Mn-1] can be feasibly be prepared on gram-scale from Mn(acac)2·2H2O in air. This dual catalytic protocol features noble-metal-free catalysts, simple ligand, and mild conditions. Besides, a unique ortho-halogen and -hydroxyl effect was observed to achieve high Z-stereoselectivity.2022-01-01T00:00:00Z2022 Dec2025-04-26T09:41:58.954Z2025-04-06T13:10:07.278ZS-EPMC97616953654507010.1039/d2ra07920h