biostudies-literatureDiez-Ricote LCIBER de Fisiopatología de la Obesidad y NutriciónAmgenConsejería de Salud y Familias, Junta de AndalucíaFEDERGeneralitat ValencianaNovo NordiskInstituto de Salud Carlos IIIEuropean Research CouncilMinisterio de Ciencia e InnovaciónInstituto DanoneFundació la Marató de TV3Catalan Institution for Research and Advanced StudiesGovernment of Navarra Department of HealthBiotechnology and Biological Sciences Research CouncilSanofiMSDEuropean Regional Development Fund1565-1579https://www.ebi.ac.uk/biostudies/studies/S-EPMC9761742biostudies-literatureUnknown116(6)<h4>Background</h4>Choline and betaine intakes have been related to cardiovascular health.<h4>Objectives</h4>We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial.<h4>Methods</h4>We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of chThe American journal of clinical nutritionOne-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial.PMC9761742#3409182013ACUP00194BB/S020845/1PCI2018-093009340918PI0137/201861/2015PI0458/2013FJC2018-038168-IPROMETEO/2017/017PS0358/2016RTI2018-095569-B-I0035/2011201630.10Concejo MJTojal-Sierra LMico VLopez-Miranda JPinto XDiez-Ricote LGaforio JJEstruch RBasterra-Gortari JGomez-Bellvert NWarnberg JChaplin AHerraiz XSalas-Salvado JVidal JMartin Sanchez VVazquez-Ruiz ZTur JAMartinez-Gonzalez MASalaverria-Lete IBueno-Cavanillas ABabio NVioque JMalcampo MGoday AMartinez-Urbistondo DGoni Ochandorena ESerra-Majem LTinahones FJMartinez JALapetra JAlonso-Gomez AMGarcia-Rios AMurphy MMas Fontao SOrdovas JMBernal-Lopez RMRomaguera DGarcia Rodriguez ASorli JVGasulla GCorella DRos EGarcia-Gavilan JFSan-Cristobal RMatia-Martin POrtega-Azorin CSantos-Lozano JMDaimiel LfalseOne-year longitudinal association between changes in dietary choline or betaine intake and cardiometabolic variables in the PREvencion con DIeta MEDiterranea-Plus (PREDIMED-Plus) trial.<h4>Background</h4>Choline and betaine intakes have been related to cardiovascular health.<h4>Objectives</h4>We aimed to explore the relation between 1-y changes in dietary intake of choline or betaine and 1-y changes in cardiometabolic and renal function traits within the frame of the PREDIMED (PREvención con DIeta MEDiterránea)-Plus trial.<h4>Methods</h4>We used baseline and 1-y follow-up data from 5613 participants (48.2% female and 51.8% male; mean ± SD age: 65.01 ± 4.91 y) to assess cardiometabolic traits, and 3367 participants to assess renal function, of the Spanish PREDIMED-Plus trial. Participants met ≥3 criteria of metabolic syndrome and had overweight or obesity [BMI (in kg/m2) ≥27 and ≤40]. These criteria were similar to those of the PREDIMED parent study. Dietary intakes of ch2022-01-01T00:00:00Z2022 Dec2025-04-04T19:49:25.777Z2025-04-04T19:49:25.777ZS-EPMC97617423612465210.1093/ajcn/nqac255