{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yuan M"],"funding":["National Dairy Council","National Heart, Lung, and Blood Institute","NHLBI NIH HHS"],"pagination":["1682-1692"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9761752"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["116(6)"],"pubmed_abstract":["<h4>Background</h4>Current dietary guidance recommends limiting intakes of saturated fats, but most fails to consider that saturated fats from different food sources may have different health effects.<h4>Objectives</h4>We aimed to evaluate the associations of saturated fats from dairy and nondairy sources with measures of body fat, inflammatory biomarkers, lipid concentrations, and lipid particle sizes and concentrations.<h4>Methods</h4>The Framingham Offspring Study is a prospective cohort study. Participants (n = 2391) ≥30 y of age who had dietary records and data on the outcomes of interest were included.<h4>Results</h4>Among females, those in the highest quintile (compared with the lowest) of dairy-derived saturated fat had lower multivariable-adjusted levels of body fat [BMI (in kg/m2): 26.2 compared with 27.8, P < 0.01; and percentage fat mass: 36.7% compared with 38.0%, P = 0.09) and larger LDL particle sizes. Nondairy saturated fat in females was inversely associated with the triglyceride (TG):HDL ratio (P = 0.03). Among males, intakes of dairy-derived saturated fats were inversely associated with C-reactive protein (P < 0.01), fibrinogen (P < 0.01), TGs (P < 0.01), and the TG:HDL ratio (P < 0.01). HDL cholesterol was 2.8 mg/dL (P = 0.04) higher among males in the highest (compared with the lowest) quintile of saturated fat from dairy sources. Males with the highest intakes of dairy-derived saturated fats had larger HDL and LDL particle sizes (P < 0.01 for both), a higher HDL particle concentration (P < 0.01), and a lower VLDL particle concentration (P < 0.01). There were no statistically significant adverse effects of saturated fats from nondairy sources on any of these outcomes in either males or females.<h4>Conclusions</h4>Males with higher intakes of dairy-derived saturated fats had a less atherogenic profile than males with lower intakes of these fats. These effects were weaker in females. Nondairy saturated fats were not associated with these cardiometabolic outcomes."],"journal":["The American journal of clinical nutrition"],"pubmed_title":["Saturated fat from dairy sources is associated with lower cardiometabolic risk in the Framingham Offspring Study."],"pmcid":["PMC9761752"],"funding_grant_id":["2854","HHSN268201500001C","N01-HC-25195","HHSN268201500001I"],"pubmed_authors":["Singer MR","Pickering RT","Yuan M","Moore LL"],"additional_accession":[]},"is_claimable":false,"name":"Saturated fat from dairy sources is associated with lower cardiometabolic risk in the Framingham Offspring Study.","description":"<h4>Background</h4>Current dietary guidance recommends limiting intakes of saturated fats, but most fails to consider that saturated fats from different food sources may have different health effects.<h4>Objectives</h4>We aimed to evaluate the associations of saturated fats from dairy and nondairy sources with measures of body fat, inflammatory biomarkers, lipid concentrations, and lipid particle sizes and concentrations.<h4>Methods</h4>The Framingham Offspring Study is a prospective cohort study. Participants (n = 2391) ≥30 y of age who had dietary records and data on the outcomes of interest were included.<h4>Results</h4>Among females, those in the highest quintile (compared with the lowest) of dairy-derived saturated fat had lower multivariable-adjusted levels of body fat [BMI (in kg/m2): 26.2 compared with 27.8, P < 0.01; and percentage fat mass: 36.7% compared with 38.0%, P = 0.09) and larger LDL particle sizes. Nondairy saturated fat in females was inversely associated with the triglyceride (TG):HDL ratio (P = 0.03). Among males, intakes of dairy-derived saturated fats were inversely associated with C-reactive protein (P < 0.01), fibrinogen (P < 0.01), TGs (P < 0.01), and the TG:HDL ratio (P < 0.01). HDL cholesterol was 2.8 mg/dL (P = 0.04) higher among males in the highest (compared with the lowest) quintile of saturated fat from dairy sources. Males with the highest intakes of dairy-derived saturated fats had larger HDL and LDL particle sizes (P < 0.01 for both), a higher HDL particle concentration (P < 0.01), and a lower VLDL particle concentration (P < 0.01). There were no statistically significant adverse effects of saturated fats from nondairy sources on any of these outcomes in either males or females.<h4>Conclusions</h4>Males with higher intakes of dairy-derived saturated fats had a less atherogenic profile than males with lower intakes of these fats. These effects were weaker in females. Nondairy saturated fats were not associated with these cardiometabolic outcomes.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-22T11:58:03.585Z","creation":"2025-04-06T00:08:02.161Z"},"accession":"S-EPMC9761752","cross_references":{"pubmed":["36307959"],"doi":["10.1093/ajcn/nqac224"]}}