{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14"],"submitter":["Lee JB"],"pubmed_abstract":["<h4>Background</h4>The clinical utility of plasma tumor mutational burden (pTMB) requires further validation. Herein, the pTMB and genetic alterations were investigated as predictive biomarkers for anti-PD-1 monotherapy outcome in metastatic non-small cell lung cancer (NSCLC).<h4>Methods</h4>The GuardantOMNI panel (Guardant Health) was used to identify pTMB and genetic alterations. Data from 99 patients with metastatic NSCLC treated with pembrolizumab or nivolumab in first-, second-, or third-line settings between June 2016 and December 2020 were collected. Associations between pTMB and clinical benefit rate (CBR, stable disease ⩾6 months or partial response), progression-free survival (PFS), and overall survival (OS) were assessed.<h4>Results</h4>Median pTMB in 84 patients was 10.8 mutations/megabase (mut/Mb). Histological analyses revealed that 61 and 36% of the patients had adenocarcinomas and squamous NSCLC, respectively. Most patients were treated with nivolumab (74%) and most anti-PD-1 agents were administered as second-line treatment (70%). The median follow-up duration was of 10.9 months (range, 0.2-40.7). Patients with high pTMB (⩾19 mut/Mb) had a higher CBR (69%) compared with low pTMB patients (33%; <i>p</i> = 0.01). <i>ARID1A</i> (<i>p</i> = 0.007) and either <i>ERBB2</i> or <i>KIT</i> mutations (<i>p</i> = 0.012) were positive and negative determinants, respectively, for clinical benefit. Multivariate analysis further showed that high pTMB was an independent predictive biomarker for both PFS [hazard ratio (HR) = 0.44, 95% confidence interval (CI): 0.22-0.88, <i>p</i> = 0.02] and OS (HR = 0.37, 95% CI: 0.18-0.76, <i>p</i> = 0.007).<h4>Conclusion</h4>High pTMB (⩾19 mut/Mb) is significantly associated with CBR in patients with NSCLC treated with anti-PD-1 agents."],"journal":["Therapeutic advances in medical oncology"],"pagination":["17588359221141761"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9761799"],"repository":["biostudies-literature"],"pubmed_title":["Plasma tumor mutation burden is associated with clinical benefit in patients with non-small cell lung cancer treated with anti-programmed death-1 monotherapy."],"pmcid":["PMC9761799"],"pubmed_authors":["Lim SM","Lee JB","Chang K","Odegaard J","Shim BY","Quinn K","Kim HR","Park HS","An HJ","Hong MH","Cho BC","Choi SJ","Heo SG"],"additional_accession":[]},"is_claimable":false,"name":"Plasma tumor mutation burden is associated with clinical benefit in patients with non-small cell lung cancer treated with anti-programmed death-1 monotherapy.","description":"<h4>Background</h4>The clinical utility of plasma tumor mutational burden (pTMB) requires further validation. Herein, the pTMB and genetic alterations were investigated as predictive biomarkers for anti-PD-1 monotherapy outcome in metastatic non-small cell lung cancer (NSCLC).<h4>Methods</h4>The GuardantOMNI panel (Guardant Health) was used to identify pTMB and genetic alterations. Data from 99 patients with metastatic NSCLC treated with pembrolizumab or nivolumab in first-, second-, or third-line settings between June 2016 and December 2020 were collected. Associations between pTMB and clinical benefit rate (CBR, stable disease ⩾6 months or partial response), progression-free survival (PFS), and overall survival (OS) were assessed.<h4>Results</h4>Median pTMB in 84 patients was 10.8 mutations/megabase (mut/Mb). Histological analyses revealed that 61 and 36% of the patients had adenocarcinomas and squamous NSCLC, respectively. Most patients were treated with nivolumab (74%) and most anti-PD-1 agents were administered as second-line treatment (70%). The median follow-up duration was of 10.9 months (range, 0.2-40.7). Patients with high pTMB (⩾19 mut/Mb) had a higher CBR (69%) compared with low pTMB patients (33%; <i>p</i> = 0.01). <i>ARID1A</i> (<i>p</i> = 0.007) and either <i>ERBB2</i> or <i>KIT</i> mutations (<i>p</i> = 0.012) were positive and negative determinants, respectively, for clinical benefit. Multivariate analysis further showed that high pTMB was an independent predictive biomarker for both PFS [hazard ratio (HR) = 0.44, 95% confidence interval (CI): 0.22-0.88, <i>p</i> = 0.02] and OS (HR = 0.37, 95% CI: 0.18-0.76, <i>p</i> = 0.007).<h4>Conclusion</h4>High pTMB (⩾19 mut/Mb) is significantly associated with CBR in patients with NSCLC treated with anti-PD-1 agents.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T08:45:07.49Z","creation":"2025-04-04T08:45:07.49Z"},"accession":"S-EPMC9761799","cross_references":{"pubmed":["36544541"],"doi":["10.1177/17588359221141761"]}}