{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Voskens C"],"funding":["Deutsche Forschungsgemeinschaft"],"pagination":["49-53"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9763232"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["72(1)"],"pubmed_abstract":["<h4>Objective</h4>Ulcerative colitis (UC) is a chronic, debilitating immune-mediated disease driven by disturbed mucosal homeostasis, with an excess of intestinal effector T cells and an insufficient expansion of mucosal regulatory T cells (Tregs). We here report on the successful adoptive transfer of autologous, ex vivo expanded Tregs in a patient with refractory UC and associated primary sclerosing cholangitis (PSC), for which effective therapy is currently not available.<h4>Design</h4>The patient received a single infusion of 1×10<sup>6</sup> autologous, ex vivo expanded, polyclonal Tregs per kilogram of body weight, and the clinical, biochemical, endoscopic and histological responses were assessed 4 and 12 weeks after adoptive Treg transfer.<h4>Results</h4>The patient showed clinical, "],"journal":["Gut"],"pubmed_title":["Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis."],"pmcid":["PMC9763232"],"funding_grant_id":["KFO257 (Project 08) and TRR241 (Project C04)"],"pubmed_authors":["Wiesinger M","Schnoy E","Kummer M","Siegmund B","Stoica D","Hartmann A","Hackstein H","Vitali F","Ganslmayer M","Rath T","Wunder J","Knott H","Atreya R","Neurath MF","Zundler S","Schuler G","Voskens C","Berking C","Schuler-Thurner B","Rosenberg M"],"additional_accession":[]},"is_claimable":false,"name":"Autologous regulatory T-cell transfer in refractory ulcerative colitis with concomitant primary sclerosing cholangitis.","description":"<h4>Objective</h4>Ulcerative colitis (UC) is a chronic, debilitating immune-mediated disease driven by disturbed mucosal homeostasis, with an excess of intestinal effector T cells and an insufficient expansion of mucosal regulatory T cells (Tregs). We here report on the successful adoptive transfer of autologous, ex vivo expanded Tregs in a patient with refractory UC and associated primary sclerosing cholangitis (PSC), for which effective therapy is currently not available.<h4>Design</h4>The patient received a single infusion of 1×10<sup>6</sup> autologous, ex vivo expanded, polyclonal Tregs per kilogram of body weight, and the clinical, biochemical, endoscopic and histological responses were assessed 4 and 12 weeks after adoptive Treg transfer.<h4>Results</h4>The patient showed clinical, ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2026-06-08T06:50:05.367Z","creation":"2026-06-08T03:14:30.709Z"},"accession":"S-EPMC9763232","cross_references":{"pubmed":["35428657"],"doi":["10.1136/gutjnl-2022-327075"]}}