biostudies-literatureUnknown4(12)Alrashidi SMcMaster UniversityHamilton Health SciencesHamilton Health Sciences Foundation<h4>Background</h4>A significant limitation of femoral artery access for cardiac interventions is the increased risk of vascular complications and bleeding compared to radial access. Ultrasound (US)-guided femoral access may reduce major vascular complications and bleeding. We aim to determine whether routinely using US guidance for femoral arterial access for coronary angiography or intervention will reduce Bleeding Academic Research Consortium (BARC) 2, 3, or 5 bleeding or major vascular complications.<h4>Methods</h4>The Ultrasound Guidance for Vascular Access for Cardiac Procedures: A Randomized Trial (UNIVERSAL) is a multicentre, prospective, open-label, randomized trial with blinded outcomes assCJC open1074-1080https://www.ebi.ac.uk/biostudies/studies/S-EPMC9764117biostudies-literatureDesign and Rationale of Routine UltrasouNd GuIdance for Vascular AccEss foR Cardiac Procedures: A Randomized TriaL (UNIVERSAL).PMC9764117Alrashidi SAkl ESchwalm JDSkuriat ECamargo MKelly ABrochu BJolly SSValettas NMehta SRd'Entremont MARaco MSheth TFaidi WNatarajan MKDutra GHeenan LAlansari OSibbald MTyrwhitt JPinilla-Echeverri NTsang MBVelianou JTawadros SWinter JfalseDesign and Rationale of Routine UltrasouNd GuIdance for Vascular AccEss foR Cardiac Procedures: A Randomized TriaL (UNIVERSAL).<h4>Background</h4>A significant limitation of femoral artery access for cardiac interventions is the increased risk of vascular complications and bleeding compared to radial access. Ultrasound (US)-guided femoral access may reduce major vascular complications and bleeding. We aim to determine whether routinely using US guidance for femoral arterial access for coronary angiography or intervention will reduce Bleeding Academic Research Consortium (BARC) 2, 3, or 5 bleeding or major vascular complications.<h4>Methods</h4>The Ultrasound Guidance for Vascular Access for Cardiac Procedures: A Randomized Trial (UNIVERSAL) is a multicentre, prospective, open-label, randomized trial with blinded outcomes ass2022-01-01T00:00:00Z2022 Dec2025-04-26T07:16:45.302Z2025-04-06T12:10:32.246ZS-EPMC97641173656201410.1016/j.cjco.2022.08.011