{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cavalli ES"],"funding":["Leverhulme Trust","GlaxoSmithKline"],"pagination":["8931-8935"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9764413"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(49)"],"pubmed_abstract":["An efficient two-step procedure for the syntheses of pyrimidine nucleosides is presented. A series of glycosyl 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives were prepared from β-anomeric isonitriles by reaction with Meldrum's acid or by allowing aminomethylene Meldrum's acid to react with an 1-aldofuranosyl halide or acetate. The resultant 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives underwent reaction with benzyl- or 2,4-dimethoxybenzyl isocyanate via transacylation to provide uridine-5-carboxylic acid derivatives and related nucleosides. These nucleoside carboxylic acids were converted into other C-5 derivatives by bromo-decarboxylation with <i>N</i>-bromosuccinimide."],"journal":["Organic letters"],"pubmed_title":["Pyrimidine Nucleosides Syntheses by Late-Stage Base Heterocyclization Reactions."],"pmcid":["PMC9764413"],"funding_grant_id":["RPG-2020-273"],"pubmed_authors":["Mies T","Cavalli ES","Rzepa HS","Parsons PJ","White AJP","Barrett AGM"],"additional_accession":[]},"is_claimable":false,"name":"Pyrimidine Nucleosides Syntheses by Late-Stage Base Heterocyclization Reactions.","description":"An efficient two-step procedure for the syntheses of pyrimidine nucleosides is presented. A series of glycosyl 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives were prepared from β-anomeric isonitriles by reaction with Meldrum's acid or by allowing aminomethylene Meldrum's acid to react with an 1-aldofuranosyl halide or acetate. The resultant 5-(aminomethylene)-1,3-dioxane-4,6-dione derivatives underwent reaction with benzyl- or 2,4-dimethoxybenzyl isocyanate via transacylation to provide uridine-5-carboxylic acid derivatives and related nucleosides. These nucleoside carboxylic acids were converted into other C-5 derivatives by bromo-decarboxylation with <i>N</i>-bromosuccinimide.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T09:49:13.583Z","creation":"2025-04-06T13:08:24.892Z"},"accession":"S-EPMC9764413","cross_references":{"pubmed":["36331529"],"doi":["10.1021/acs.orglett.2c03152"]}}