{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24(49)"],"submitter":["Bacaicoa S"],"funding":["Adlerbertska Research Foundation","Stiftelserna Wilhelm och Martina Lundgrens"],"pubmed_abstract":["Herein, we present an accessible aerobic N-heterocyclic carbene (NHC)-catalyzed method that efficiently produces tetrasubstituted benzene rings in a single reaction. The method employs atmospheric oxygen (O<sub>2</sub>) as the terminal oxidant in a reaction that requires two oxidative steps. The aerobic oxidation is achieved by a selection of electron transfer mediators orchestrating a redox cascade, turning a high-energy aerobic oxidation reaction pathway into a favorable process."],"journal":["Organic letters"],"pagination":["9146-9150"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9764416"],"repository":["biostudies-literature"],"pubmed_title":["Aerobic Oxidative N-Heterocyclic Carbene-Catalyzed Formal [3+3] Cyclization for the Synthesis of Tetrasubstituted Benzene Derivatives."],"pmcid":["PMC9764416"],"pubmed_authors":["Goossens E","Sunden H","Bacaicoa S"],"additional_accession":[]},"is_claimable":false,"name":"Aerobic Oxidative N-Heterocyclic Carbene-Catalyzed Formal [3+3] Cyclization for the Synthesis of Tetrasubstituted Benzene Derivatives.","description":"Herein, we present an accessible aerobic N-heterocyclic carbene (NHC)-catalyzed method that efficiently produces tetrasubstituted benzene rings in a single reaction. The method employs atmospheric oxygen (O<sub>2</sub>) as the terminal oxidant in a reaction that requires two oxidative steps. The aerobic oxidation is achieved by a selection of electron transfer mediators orchestrating a redox cascade, turning a high-energy aerobic oxidation reaction pathway into a favorable process.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-26T09:43:06.701Z","creation":"2025-04-06T13:08:29.644Z"},"accession":"S-EPMC9764416","cross_references":{"pubmed":["36469618"],"doi":["10.1021/acs.orglett.2c03879"]}}