biostudies-literatureUnknown24(49)Bacaicoa SAdlerbertska Research FoundationStiftelserna Wilhelm och Martina LundgrensHerein, we present an accessible aerobic N-heterocyclic carbene (NHC)-catalyzed method that efficiently produces tetrasubstituted benzene rings in a single reaction. The method employs atmospheric oxygen (O₂) as the terminal oxidant in a reaction that requires two oxidative steps. The aerobic oxidation is achieved by a selection of electron transfer mediators orchestrating a redox cascade, turning a high-energy aerobic oxidation reaction pathway into a favorable process.Organic letters9146-9150https://www.ebi.ac.uk/biostudies/studies/S-EPMC9764416biostudies-literatureAerobic Oxidative N-Heterocyclic Carbene-Catalyzed Formal [3+3] Cyclization for the Synthesis of Tetrasubstituted Benzene Derivatives.PMC9764416Goossens ESunden HBacaicoa SfalseAerobic Oxidative N-Heterocyclic Carbene-Catalyzed Formal [3+3] Cyclization for the Synthesis of Tetrasubstituted Benzene Derivatives.Herein, we present an accessible aerobic N-heterocyclic carbene (NHC)-catalyzed method that efficiently produces tetrasubstituted benzene rings in a single reaction. The method employs atmospheric oxygen (O₂) as the terminal oxidant in a reaction that requires two oxidative steps. The aerobic oxidation is achieved by a selection of electron transfer mediators orchestrating a redox cascade, turning a high-energy aerobic oxidation reaction pathway into a favorable process.2022-01-01T00:00:00Z2022 Dec2025-04-26T09:43:06.701Z2025-04-06T13:08:29.644ZS-EPMC97644163646961810.1021/acs.orglett.2c03879