{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu YXY"],"funding":["National Natural Science Foundation of China"],"pagination":["475"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9764493"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["15(1)"],"pubmed_abstract":["<h4>Background</h4>Trichinella spiralis is an important foodborne parasite that presents a severe threat to food safety. The development of an anti-Trichinella vaccine is an important step towards controlling Trichinella infection in food animals and thus ensure meat safety. Trichinella spiralis galectin (Tsgal) is a novel protein that has been identified on the surface of this nematode. Recombinant Tsgal (rTsgal) was found to participate in larval invasion of intestinal epithelium cells (IECs), whereas anti-rTsgal antibodies impeded the invasion.<h4>Methods</h4>The rTsgal/pSIP409- pgsA' plasmid was constructed and transferred into Lactobacillus plantarum strain NC8, following which the in vitro biological properties of rTsgal/NC8 were determined. Five groups of mice were orally immunized "],"journal":["Parasites & vectors"],"pubmed_title":["Oral immunization of mice with recombinant Lactobacillus plantarum expressing a Trichinella spiralis galectin induces an immune protection against larval challenge."],"pmcid":["PMC9764493"],"funding_grant_id":["82172300","82272367"],"pubmed_authors":["Zhang XZ","Long SR","Cheng YK","Wang ZQ","Liu RD","Cui J","Xu YXY","Weng MM"],"additional_accession":[]},"is_claimable":false,"name":"Oral immunization of mice with recombinant Lactobacillus plantarum expressing a Trichinella spiralis galectin induces an immune protection against larval challenge.","description":"<h4>Background</h4>Trichinella spiralis is an important foodborne parasite that presents a severe threat to food safety. The development of an anti-Trichinella vaccine is an important step towards controlling Trichinella infection in food animals and thus ensure meat safety. Trichinella spiralis galectin (Tsgal) is a novel protein that has been identified on the surface of this nematode. Recombinant Tsgal (rTsgal) was found to participate in larval invasion of intestinal epithelium cells (IECs), whereas anti-rTsgal antibodies impeded the invasion.<h4>Methods</h4>The rTsgal/pSIP409- pgsA' plasmid was constructed and transferred into Lactobacillus plantarum strain NC8, following which the in vitro biological properties of rTsgal/NC8 were determined. Five groups of mice were orally immunized ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-07-14T15:08:09.836Z","creation":"2025-02-19T03:24:24.417Z"},"accession":"S-EPMC9764493","cross_references":{"pubmed":["36539832"],"doi":["10.1186/s13071-022-05597-w"]}}