biostudies-literatureUnknown22(1)Graneli CLund University<h4>Background</h4>In the validation of new imaging technology for children with Hirschsprung's disease (HSCR), basic anatomical parameters of the bowel wall must be established specifically for this patient group.<h4>Aim</h4>To explore differences in histoanatomical layers of bowel wall, comparing ganglionic and aganglionic bowel walls, and to examine if the bowel wall thickness is linked to patient weight.<h4>Methods</h4>This was an observational study of bowel specimens from children weighing 0-10 kg, operated on consecutively during 2018-2020. Ganglionic and aganglionic bowel walls were measured in digitalized microscopy images from 10 sites per trans-sectional specimen and compared regarding the thickness of their histoanatomical layers.<h4>Results</h4>Bowel walls were measured in 21 BMC pediatrics723https://www.ebi.ac.uk/biostudies/studies/S-EPMC9764572biostudies-literatureHistopathological dimensions differ between aganglionic and ganglionic bowel wall in children with Hirschsprung's disease.PMC9764572Gottberg ECinthio MMitev RMStenstrom PHagelsteen KErlov TGisselsson DJansson TGraneli CPatarroyo SfalseHistopathological dimensions differ between aganglionic and ganglionic bowel wall in children with Hirschsprung's disease.<h4>Background</h4>In the validation of new imaging technology for children with Hirschsprung's disease (HSCR), basic anatomical parameters of the bowel wall must be established specifically for this patient group.<h4>Aim</h4>To explore differences in histoanatomical layers of bowel wall, comparing ganglionic and aganglionic bowel walls, and to examine if the bowel wall thickness is linked to patient weight.<h4>Methods</h4>This was an observational study of bowel specimens from children weighing 0-10 kg, operated on consecutively during 2018-2020. Ganglionic and aganglionic bowel walls were measured in digitalized microscopy images from 10 sites per trans-sectional specimen and compared regarding the thickness of their histoanatomical layers.<h4>Results</h4>Bowel walls were measured in 21 2022-01-01T00:00:00Z2022 Dec2025-04-04T22:36:30.744Z2024-11-19T15:24:28.901ZS-EPMC97645723653631310.1186/s12887-022-03792-3