{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["AbuEid M"],"funding":["NIGMS NIH HHS"],"pagination":["105670"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9768319"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["25(12)"],"pubmed_abstract":["Triphenylphosphonium (TPP<sup>+</sup>) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP<sup>+</sup>-conjugated compounds. Here, we investigated the biological effects of direct modification to TPP<sup>+</sup> to improve the efficacy and detection of mito-metformin (MMe), a TPP<sup>+</sup>-conjugated probe we have shown to have promising preclinical efficacy against solid cancer cells. We designed, synthesized, and tested trifluoromethyl and methoxy MMe analogs (<i>p</i>CF<sub>3</sub>-MMe, <i>m</i>CF<sub>3</sub>-MMe, and <i>p</i>MeO-MMe) against multiple distinct human cancer cells. <i>p</i>CF<sub>3</sub>-MMe showed enhanced selectivity to"],"journal":["iScience"],"pubmed_title":["Fluorinated triphenylphosphonium analogs improve cell selectivity and <i>in vivo</i> detection of mito-metformin."],"pmcid":["PMC9768319"],"funding_grant_id":["R35 GM128840"],"pubmed_authors":["McAllister D","Smith BC","Kadamberi IP","Chaluvally-Raghavan P","AbuEid M","Keyes RF","Peterson F","Sprague DJ","Dwinell MB"],"additional_accession":[]},"is_claimable":false,"name":"Fluorinated triphenylphosphonium analogs improve cell selectivity and <i>in vivo</i> detection of mito-metformin.","description":"Triphenylphosphonium (TPP<sup>+</sup>) conjugated compounds selectively target cancer cells by exploiting their hyperpolarized mitochondrial membrane potential. To date, studies have focused on modifying either the linker or the cargo of TPP<sup>+</sup>-conjugated compounds. Here, we investigated the biological effects of direct modification to TPP<sup>+</sup> to improve the efficacy and detection of mito-metformin (MMe), a TPP<sup>+</sup>-conjugated probe we have shown to have promising preclinical efficacy against solid cancer cells. We designed, synthesized, and tested trifluoromethyl and methoxy MMe analogs (<i>p</i>CF<sub>3</sub>-MMe, <i>m</i>CF<sub>3</sub>-MMe, and <i>p</i>MeO-MMe) against multiple distinct human cancer cells. <i>p</i>CF<sub>3</sub>-MMe showed enhanced selectivity to","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-05T14:56:58.08Z","creation":"2025-04-05T14:56:58.08Z"},"accession":"S-EPMC9768319","cross_references":{"pubmed":["36567718"],"doi":["10.1016/j.isci.2022.105670"]}}