{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jackson N"],"funding":["BioAmp","NIAID NIH HHS","HHS | NIH | National Institute of Allergy and Infectious Diseases"],"pagination":["e0047122"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9769571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(6)"],"pubmed_abstract":["Antimicrobial resistance in urinary tract infections (UTIs) is a major public health concern. This study aims to characterize the phenotypic and genetic basis of multidrug resistance (MDR) among expanded-spectrum cephalosporin-resistant (ESCR) uropathogenic Escherichia coli (UPEC) causing UTIs in California patient populations. Between February and October 2019, 577 ESCR UPEC isolates were collected from patients at 6 clinical laboratory sites across California. Lineage and antibiotic resistance genes were determined by analysis of whole-genome sequence data. The lineages ST131, ST1193, ST648, and ST69 were predominant, representing 46%, 5.5%, 4.5%, and 4.5% of the collection, respectively. Overall, 527 (91%) isolates had an expanded-spectrum β-lactamase (ESBL) phenotype, with <i>bla</i><s"],"journal":["mSphere"],"pubmed_title":["Genetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance."],"pmcid":["PMC9769571"],"funding_grant_id":["Gift fund","R01 AI117064","R01AI117064"],"pubmed_authors":["Fee C","Huang YY","Riley LW","Crandall C","Miller S","Bittencourt CE","Kane I","Mastrangelo CF","Hufana C","Coralic Z","Tarlton NJ","Jackson N","Garner O","Allegretti YH","Chandrasekaran S","Noorbakhsh MH","Parker A","Frazee BW","Diaz J","Marcha JC","Awasthi S","Rodrigues-Wong P","deBoer TR","Borges CA","Belmont CR","Adams-Sapper S","Florence-Petrovic D"],"additional_accession":[]},"is_claimable":false,"name":"Genetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance.","description":"Antimicrobial resistance in urinary tract infections (UTIs) is a major public health concern. This study aims to characterize the phenotypic and genetic basis of multidrug resistance (MDR) among expanded-spectrum cephalosporin-resistant (ESCR) uropathogenic Escherichia coli (UPEC) causing UTIs in California patient populations. Between February and October 2019, 577 ESCR UPEC isolates were collected from patients at 6 clinical laboratory sites across California. Lineage and antibiotic resistance genes were determined by analysis of whole-genome sequence data. The lineages ST131, ST1193, ST648, and ST69 were predominant, representing 46%, 5.5%, 4.5%, and 4.5% of the collection, respectively. Overall, 527 (91%) isolates had an expanded-spectrum β-lactamase (ESBL) phenotype, with <i>bla</i><s","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-12T09:58:01.073Z","creation":"2024-11-10T03:46:50.107Z"},"accession":"S-EPMC9769571","cross_references":{"pubmed":["36377882"],"doi":["10.1128/msphere.00471-22"]}}