biostudies-literatureJackson NBioAmpNIAID NIH HHSHHS | NIH | National Institute of Allergy and Infectious Diseasese0047122https://www.ebi.ac.uk/biostudies/studies/S-EPMC9769571biostudies-literatureUnknown7(6)Antimicrobial resistance in urinary tract infections (UTIs) is a major public health concern. This study aims to characterize the phenotypic and genetic basis of multidrug resistance (MDR) among expanded-spectrum cephalosporin-resistant (ESCR) uropathogenic Escherichia coli (UPEC) causing UTIs in California patient populations. Between February and October 2019, 577 ESCR UPEC isolates were collected from patients at 6 clinical laboratory sites across California. Lineage and antibiotic resistance genes were determined by analysis of whole-genome sequence data. The lineages ST131, ST1193, ST648, and ST69 were predominant, representing 46%, 5.5%, 4.5%, and 4.5% of the collection, respectively. Overall, 527 (91%) isolates had an expanded-spectrum β-lactamase (ESBL) phenotype, with <i>bla</i><smSphereGenetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance.PMC9769571Gift fundR01 AI117064R01AI117064Fee CHuang YYRiley LWCrandall CMiller SBittencourt CEKane IMastrangelo CFHufana CCoralic ZTarlton NJJackson NGarner OAllegretti YHChandrasekaran SNoorbakhsh MHParker AFrazee BWDiaz JMarcha JCAwasthi SRodrigues-Wong PdeBoer TRBorges CABelmont CRAdams-Sapper SFlorence-Petrovic DfalseGenetic Predictive Factors for Nonsusceptible Phenotypes and Multidrug Resistance in Expanded-Spectrum Cephalosporin-Resistant Uropathogenic Escherichia coli from a Multicenter Cohort: Insights into the Phenotypic and Genetic Basis of Coresistance.Antimicrobial resistance in urinary tract infections (UTIs) is a major public health concern. This study aims to characterize the phenotypic and genetic basis of multidrug resistance (MDR) among expanded-spectrum cephalosporin-resistant (ESCR) uropathogenic Escherichia coli (UPEC) causing UTIs in California patient populations. Between February and October 2019, 577 ESCR UPEC isolates were collected from patients at 6 clinical laboratory sites across California. Lineage and antibiotic resistance genes were determined by analysis of whole-genome sequence data. The lineages ST131, ST1193, ST648, and ST69 were predominant, representing 46%, 5.5%, 4.5%, and 4.5% of the collection, respectively. Overall, 527 (91%) isolates had an expanded-spectrum β-lactamase (ESBL) phenotype, with <i>bla</i><s2022-01-01T00:00:00Z2022 Dec2026-06-12T09:58:01.073Z2024-11-10T03:46:50.107ZS-EPMC97695713637788210.1128/msphere.00471-22