{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Vangeti S"],"funding":["DOD | Defense Health Agency","Swedish Research Council","DOD | Defense Advanced Research Projects Agency"],"pagination":["e0183722"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9769986"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["We investigated the temporal profile of multiple components of the serological response after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously SARS-CoV-2 naive young adults, up to 8.5 months after infection. We found a significant decrease of spike IgG and neutralization antibody titers from early (11 to 56 days) to late (4 to 8.5 months) time points postinfection. Over the study period, S1-specific IgG levels declined significantly faster than that of the S2-specific IgG. Further, serum antibodies from PCR-confirmed participants cross-recognized S2, but not S1, of the betacoronaviruses HKU1 and OC43, suggesting a greater degree of cross-reactivity of S2 among betacoronaviruses. Antibody-Dependent Natural Killer cell Activation (ADNKA) was detected at t"],"journal":["Microbiology spectrum"],"pubmed_title":["Serum Fc-Mediated Monocyte Phagocytosis Activity Is Stable for Several Months after SARS-CoV-2 Asymptomatic and Mildly Symptomatic Infection."],"pmcid":["PMC9769986"],"funding_grant_id":["N6600119C4022","2021-06713","9700130"],"pubmed_authors":["Balinsky CA","Periasamy S","Sugiharto VA","Nunez E","Vangeti S","Marayag J","Goforth CW","George MC","Sun P","Yu XB","Marrone A","Ge Y","Soares-Schanoski A","Jani V","Schilling M","Letizia AG","Bukreyev A","Mahajan AS","Lizewski R","Marjanovic N","Ramos I","Sealfon SC","Cooper E","Porter CK","Kuzmina NA","Beckett C","Lizewski SE"],"additional_accession":[]},"is_claimable":false,"name":"Serum Fc-Mediated Monocyte Phagocytosis Activity Is Stable for Several Months after SARS-CoV-2 Asymptomatic and Mildly Symptomatic Infection.","description":"We investigated the temporal profile of multiple components of the serological response after asymptomatic or mildly symptomatic SARS-CoV-2 infection, in a cohort of 67 previously SARS-CoV-2 naive young adults, up to 8.5 months after infection. We found a significant decrease of spike IgG and neutralization antibody titers from early (11 to 56 days) to late (4 to 8.5 months) time points postinfection. Over the study period, S1-specific IgG levels declined significantly faster than that of the S2-specific IgG. Further, serum antibodies from PCR-confirmed participants cross-recognized S2, but not S1, of the betacoronaviruses HKU1 and OC43, suggesting a greater degree of cross-reactivity of S2 among betacoronaviruses. Antibody-Dependent Natural Killer cell Activation (ADNKA) was detected at t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-12T09:51:53.933Z","creation":"2025-04-05T14:54:51.62Z"},"accession":"S-EPMC9769986","cross_references":{"pubmed":["36374040"],"doi":["10.1128/spectrum.01837-22"]}}