{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Jong BE"],"funding":["Ministry of Science and Technology, Taiwan","Der-Ling Cheng Foundation","Chang Gung Medical Foundation"],"pagination":["e0274922"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9769998"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(6)"],"pubmed_abstract":["Our previous study identified that the Mycobacterium abscessus subsp. <i>abscessus</i> T28 sequevar does not fully represent inducible macrolide resistance. Thus, we initiated a correlation study between genotypes and phenotypes. In total, 75 isolates from patients with skin and soft tissue infections were enrolled in the study. These strains were tested against 11 antimycobacterial agents using Sensitire RAPMYCO plates and the CLSI-recommended broth microdilution method. In order to analyze <i>erm</i>(41) and partial <i>hsp65</i>, <i>rpoB</i>, <i>secA1</i>, and <i>rrl</i> genes, bacterial genomic DNA was extracted from bacteria. The MEGA X software was used for phylogenetic analyses. The most active agents against most M. abscessus species were amikacin and tigecycline. Clarithromycin was"],"journal":["Microbiology spectrum"],"pubmed_title":["Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species."],"pmcid":["PMC9769998"],"funding_grant_id":["107-2314-B-182A-131-MY3","CMRPG3L0411-2"],"pubmed_authors":["Lai HC","Jong BE","Shu CC","Chiu CH","Lu JJ","Chung WH","Wang LS","Wu TL","Chen NY","Yang CH","Wu TS"],"additional_accession":[]},"is_claimable":false,"name":"Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species.","description":"Our previous study identified that the Mycobacterium abscessus subsp. <i>abscessus</i> T28 sequevar does not fully represent inducible macrolide resistance. Thus, we initiated a correlation study between genotypes and phenotypes. In total, 75 isolates from patients with skin and soft tissue infections were enrolled in the study. These strains were tested against 11 antimycobacterial agents using Sensitire RAPMYCO plates and the CLSI-recommended broth microdilution method. In order to analyze <i>erm</i>(41) and partial <i>hsp65</i>, <i>rpoB</i>, <i>secA1</i>, and <i>rrl</i> genes, bacterial genomic DNA was extracted from bacteria. The MEGA X software was used for phylogenetic analyses. The most active agents against most M. abscessus species were amikacin and tigecycline. Clarithromycin was","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-07T07:32:39.858Z","creation":"2025-04-04T21:01:00.246Z"},"accession":"S-EPMC9769998","cross_references":{"pubmed":["36416559"],"doi":["10.1128/spectrum.02749-22"]}}