{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Jiang X"],"pubmed_abstract":["Breast cancer (BRCA) is a complex disease that leads to major mortalities and unsatisfactory clinical outcomes among women worldwide. CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) is a potential tumor suppressor and regulator of PD-L1, which has been found as a functional signature in considerable oncogenesis, progression, and therapeutic resistance <i>via</i> deletion and downregulation. In this research, triple-negative breast cancer (BRCA), a molecular subtype having a lower response to endocrinotherapy but a higher response to chemotherapy and immunotherapy, showed higher transcriptional levels of CMTM7. Moreover, CMTM7 positively correlated with immunomodulators, tumor-infiltrating immune cells (TIICs), and immune checkpoints in many independent datasets. Furthermore, in "],"journal":["Frontiers in genetics"],"pagination":["1051269"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9770089"],"repository":["biostudies-literature"],"pubmed_title":["CMTM7 recognizes an immune-hot tumor microenvironment and predicts therapeutic response of immunotherapy in breast cancer well."],"pmcid":["PMC9770089"],"pubmed_authors":["Yin Y","Qian Z","Zhao C","Jiang X","Zhou T","Chen Y"],"additional_accession":[]},"is_claimable":false,"name":"CMTM7 recognizes an immune-hot tumor microenvironment and predicts therapeutic response of immunotherapy in breast cancer well.","description":"Breast cancer (BRCA) is a complex disease that leads to major mortalities and unsatisfactory clinical outcomes among women worldwide. CKLF-like MARVEL transmembrane domain-containing 7 (CMTM7) is a potential tumor suppressor and regulator of PD-L1, which has been found as a functional signature in considerable oncogenesis, progression, and therapeutic resistance <i>via</i> deletion and downregulation. In this research, triple-negative breast cancer (BRCA), a molecular subtype having a lower response to endocrinotherapy but a higher response to chemotherapy and immunotherapy, showed higher transcriptional levels of CMTM7. Moreover, CMTM7 positively correlated with immunomodulators, tumor-infiltrating immune cells (TIICs), and immune checkpoints in many independent datasets. Furthermore, in ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T21:54:50.906Z","creation":"2024-11-20T22:40:11.777Z"},"accession":"S-EPMC9770089","cross_references":{"pubmed":["36568362"],"doi":["10.3389/fgene.2022.1051269"]}}