{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2022"],"submitter":["Hu R"],"funding":["Top Talent Support Program for young and middle-aged people of Wuxi Health Committee","Youth Medical Talent of Jiangsu Province"],"pubmed_abstract":["<h4>Background</h4> Klebsiella pneumoniae (K. pneu) is a leading cause of gram-negative pneumonia, which requires effective treatment. Adipose-derived mesenchymal stem cell- (ADSC-) derived exosomal microRNAs (miRNAs) have presented the inhibitory effect of multiple diseases. However, the function of ADSC-derived exosomal miRNAs in K. pneu remains unclear. <h4>Aim</h4>  In this study, we aimed to explore the effect of ADSC-derived exosomal miR-181-5p on K. pneu infection-induced lung injury. <h4>Methods</h4>  C57BL/6 mouse model was established by infection of K. pneu. ADSCs and exosomes were extracted and characterized in vitro. The translocation of ADSC-derived exosomes to bone marrow-derived macrophages (BMDMs) was detected. The level of miR-181a-5p was detected by real-time PCR. The se"],"journal":["Mediators of inflammation"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9771653"],"repository":["biostudies-literature"],"pubmed_title":["MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling"],"pmcid":["PMC9771653"],"funding_grant_id":["BJ2020092","QNRC2016163"],"pubmed_authors":["Xu L","Liu J","Rui X","Wan L","Lu J","Pei H","Chen X","Hu R"],"additional_accession":[]},"is_claimable":false,"name":"MiR-181a-5p Delivered by Adipose-Derived Mesenchymal Stem Cell Exosomes Alleviates Klebsiella pneumonia Infection-Induced Lung Injury by Targeting STAT3 Signaling","description":"<h4>Background</h4> Klebsiella pneumoniae (K. pneu) is a leading cause of gram-negative pneumonia, which requires effective treatment. Adipose-derived mesenchymal stem cell- (ADSC-) derived exosomal microRNAs (miRNAs) have presented the inhibitory effect of multiple diseases. However, the function of ADSC-derived exosomal miRNAs in K. pneu remains unclear. <h4>Aim</h4>  In this study, we aimed to explore the effect of ADSC-derived exosomal miR-181-5p on K. pneu infection-induced lung injury. <h4>Methods</h4>  C57BL/6 mouse model was established by infection of K. pneu. ADSCs and exosomes were extracted and characterized in vitro. The translocation of ADSC-derived exosomes to bone marrow-derived macrophages (BMDMs) was detected. The level of miR-181a-5p was detected by real-time PCR. The se","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-05T13:54:31.165Z","creation":"2024-11-20T22:41:03.606Z"},"accession":"S-EPMC9771653","cross_references":{}}