{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Papazoglou A"],"funding":["National Institute of Arthritis and Musculoskeletal and Skin Diseases","NIAID NIH HHS","Burroughs Wellcome Fund","NHLBI NIH HHS","NIAMS NIH HHS"],"pagination":["2003-2014"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9771864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74(12)"],"pubmed_abstract":["<h4>Objective</h4>Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of death in patients with SSc with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profibrotic secreted phosphoprotein 1 (SPP1)-expressing macrophages in SSc-ILD. This study was undertaken to define the transcriptome and chromatin structural changes of SPP1 SSc-ILD macrophages in order to better understand their role in promoting fibrosis and to identify transcription factors associated with open chromatin driving their altered phenotype.<h4>Methods</h4>We performed single-cell RNA sequencing (scRNA-Seq) on 11 explanted SSc-ILD and healthy control lung samples, as well as single-cell assay for transposase-accessible chromatin sequenci"],"journal":["Arthritis & rheumatology (Hoboken, N.J.)"],"pubmed_title":["Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis-Associated Interstitial Lung Disease."],"pmcid":["PMC9771864"],"funding_grant_id":["The University of Pittsburgh holds a Physician‐Sci","P50 AR060780","2P50AR060780","T32 AI089443","R01 HL123766"],"pubmed_authors":["Morse C","Rojas M","Papazoglou A","Tabib T","Sembrat J","Huang M","Lafyatis R","Lafyatis A","Bulik M","Valenzi E"],"additional_accession":[]},"is_claimable":false,"name":"Epigenetic Regulation of Profibrotic Macrophages in Systemic Sclerosis-Associated Interstitial Lung Disease.","description":"<h4>Objective</h4>Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of death in patients with SSc with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profibrotic secreted phosphoprotein 1 (SPP1)-expressing macrophages in SSc-ILD. This study was undertaken to define the transcriptome and chromatin structural changes of SPP1 SSc-ILD macrophages in order to better understand their role in promoting fibrosis and to identify transcription factors associated with open chromatin driving their altered phenotype.<h4>Methods</h4>We performed single-cell RNA sequencing (scRNA-Seq) on 11 explanted SSc-ILD and healthy control lung samples, as well as single-cell assay for transposase-accessible chromatin sequenci","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-22T13:16:21.21Z","creation":"2025-04-06T00:33:35.467Z"},"accession":"S-EPMC9771864","cross_references":{"pubmed":["35849803"],"doi":["10.1002/art.42286"]}}