biostudies-literatureWhellan DNIA NIH HHSe009695https://www.ebi.ac.uk/biostudies/studies/S-EPMC9771880biostudies-literatureUnknown15(12)<h4>Background</h4>As patients with heart failure experience worsening of their condition, including acute decompensated heart failure, quality of life deteriorates. However, the trajectory of quality of life changes and their determinants in the context of the Rehabilitation Therapy in Older Acute Heart Failure Patients trial physical rehabilitation intervention are unknown.<h4>Methods</h4>Patients ≥60 years old admitted for acute decompensated heart failure (n=349) were randomized to either attention control or intervention. Quality of life outcomes (Kansas City Cardiomyopathy Questionnaire; 12-Item Short-Form Health Survey) were measured at baseline (inpatient), 1 month, and 3 months. Intervention effects were assessed using linear mixed effects regression, including covariates to modelCirculation. Heart failureQuality of Life Trajectory and Its Mediators in Older Patients With Acute Decompensated Heart Failure Receiving a Multi-Domain Rehabilitation Intervention: Results From the Rehabilitation Therapy in Older Acute Heart Failure Patients Trial.PMC9771880P30 AG021332U24 AG059624R01 AG018915R01 AG045551P30 AG028716Pastva AMKitzman DWMentz RJReeves GNelson MBMcCarey MMWhellan DReed SDChen HDuncan PfalseQuality of Life Trajectory and Its Mediators in Older Patients With Acute Decompensated Heart Failure Receiving a Multi-Domain Rehabilitation Intervention: Results From the Rehabilitation Therapy in Older Acute Heart Failure Patients Trial.<h4>Background</h4>As patients with heart failure experience worsening of their condition, including acute decompensated heart failure, quality of life deteriorates. However, the trajectory of quality of life changes and their determinants in the context of the Rehabilitation Therapy in Older Acute Heart Failure Patients trial physical rehabilitation intervention are unknown.<h4>Methods</h4>Patients ≥60 years old admitted for acute decompensated heart failure (n=349) were randomized to either attention control or intervention. Quality of life outcomes (Kansas City Cardiomyopathy Questionnaire; 12-Item Short-Form Health Survey) were measured at baseline (inpatient), 1 month, and 3 months. Intervention effects were assessed using linear mixed effects regression, including covariates to model2022-01-01T00:00:00Z2022 Dec2025-05-29T21:47:01.748Z2025-05-29T21:47:01.748ZS-EPMC97718803634582510.1161/circheartfailure.122.00969510.1161/CIRCHEARTFAILURE.122.009695