{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Maurer MS"],"funding":["NIA NIH HHS","NHLBI NIH HHS","National Institute on Aging"],"pagination":["3538-3548"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9771886"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["70(12)"],"pubmed_abstract":["<h4>Background</h4>Lumbar spinal stenosis (LSS) is a common reason for spine surgery in which ligamentum flavum is resected. Transthyretin (TTR) amyloid is an often unrecognized and potentially modifiable mechanism for LSS that can also cause TTR cardiac amyloidosis. Accordingly, older adult patients undergoing lumbar spine (LS) surgery were evaluated for amyloid and if present, the precursor protein, as well as comprehensive characterization of the clinical phenotype.<h4>Methods</h4>A prospective, cohort study in 2 academic medical centers enrolled 47 subjects (age 69 ± 7 years, 53% male) undergoing clinically indicated LS decompression. The presence of amyloid was evaluated by Congo Red staining and in those with amyloid, precursor protein was determined by laser capture microdissection "],"journal":["Journal of the American Geriatrics Society"],"pubmed_title":["Analysis of lumbar spine stenosis specimens for identification of amyloid."],"pmcid":["PMC9771886"],"funding_grant_id":["R01 HL139671","K24 AG036778","R21 AG058348"],"pubmed_authors":["Blaner WS","Smiley D","Giles JT","Maurer MS","Riesenburger RI","Simsolo E","Teruya S","Bustamante A","Lehman R","Patel AR","Helmke S","Kelly JW","Varga C","Einstein AJ","Kryzanski J","Tsai F","Remotti F","Brun PJ"],"additional_accession":[]},"is_claimable":false,"name":"Analysis of lumbar spine stenosis specimens for identification of amyloid.","description":"<h4>Background</h4>Lumbar spinal stenosis (LSS) is a common reason for spine surgery in which ligamentum flavum is resected. Transthyretin (TTR) amyloid is an often unrecognized and potentially modifiable mechanism for LSS that can also cause TTR cardiac amyloidosis. Accordingly, older adult patients undergoing lumbar spine (LS) surgery were evaluated for amyloid and if present, the precursor protein, as well as comprehensive characterization of the clinical phenotype.<h4>Methods</h4>A prospective, cohort study in 2 academic medical centers enrolled 47 subjects (age 69 ± 7 years, 53% male) undergoing clinically indicated LS decompression. The presence of amyloid was evaluated by Congo Red staining and in those with amyloid, precursor protein was determined by laser capture microdissection ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-29T03:55:23.459Z","creation":"2025-04-04T09:39:49.481Z"},"accession":"S-EPMC9771886","cross_references":{"pubmed":["35929177"],"doi":["10.1111/jgs.17976"]}}