biostudies-literatureCorrigan DTNCATS NIH HHSNIAID NIH HHS22-35https://www.ebi.ac.uk/biostudies/studies/S-EPMC9771891biostudies-literatureUnknown31(1)Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.Trends in microbiologyMonoclonal antibodies to lipoarabinomannan/arabinomannan - characteristics and implications for tuberculosis research and diagnostics.PMC9771891R21 AI127173R01 AI146329R01 AI132680TL1 TR002557T32 AI070117UL1 TR002556R01 AI117927TL1 TR001072Achkar JMCorrigan DTLowary TLIshida EChatterjee DfalseMonoclonal antibodies to lipoarabinomannan/arabinomannan - characteristics and implications for tuberculosis research and diagnostics.Antibodies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysaccharide arabinomannan (AM) are increasingly important for investigations focused on both understanding mechanisms of protection against Mycobacterium tuberculosis (Mtb) and developing next-generation point-of-care tuberculosis (TB) diagnostics. We provide here an overview of the growing pipeline of monoclonal antibodies (mAbs) to LAM/AM. Old and new methodologies for their generation are reviewed and we outline and discuss their glycan epitope specificity and other features with implications for the TB field.2023-01-01T00:00:00Z2023 Jan2025-04-05T15:54:38.158Z2025-04-05T15:54:38.158ZS-EPMC97718913591824710.1016/j.tim.2022.07.001