{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Xu S"],"funding":["NIGMS NIH HHS","U.S. Department of Health & Human Services | National Institutes of Health"],"pagination":["1459-1469"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9772297"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["14(12)"],"pubmed_abstract":["Molecules that contain one or more fluorine atoms are crucial to drug discovery. There are protocols available for the selective synthesis of different organofluorine compounds, including those with a fluoro-substituted or a trifluoromethyl-substituted stereogenic carbon centre. However, approaches for synthesizing compounds with a trifluoromethyl- and fluoro-substituent stereogenic carbon centre are far less common. This potentially impactful set of molecules thus remains severely underdeveloped. Here we introduce a catalytic regio-, diastereo- and enantioselective strategy for the preparation of homoallylic alcohols bearing a stereogenic carbon centre bound to a trifluoromethyl group and a fluorine atom. The process, which involves a polyfluoroallyl boronate and is catalysed by an in sit"],"journal":["Nature chemistry"],"pubmed_title":["Diastereo- and enantioselective synthesis of compounds with a trifluoromethyl- and fluoro-substituted carbon centre."],"pmcid":["PMC9772297"],"funding_grant_id":["R35 GM128779","GM-130395","R35 GM130395","GM-128779"],"pubmed_authors":["Hu S","Romiti F","Lee J","Liu P","Fu Y","Lee K","Li X","Del Pozo J","Morrison RJ","Mai BK","Xu S","Hoveyda AH","Koh MJ"],"additional_accession":[]},"is_claimable":false,"name":"Diastereo- and enantioselective synthesis of compounds with a trifluoromethyl- and fluoro-substituted carbon centre.","description":"Molecules that contain one or more fluorine atoms are crucial to drug discovery. There are protocols available for the selective synthesis of different organofluorine compounds, including those with a fluoro-substituted or a trifluoromethyl-substituted stereogenic carbon centre. However, approaches for synthesizing compounds with a trifluoromethyl- and fluoro-substituent stereogenic carbon centre are far less common. This potentially impactful set of molecules thus remains severely underdeveloped. Here we introduce a catalytic regio-, diastereo- and enantioselective strategy for the preparation of homoallylic alcohols bearing a stereogenic carbon centre bound to a trifluoromethyl group and a fluorine atom. The process, which involves a polyfluoroallyl boronate and is catalysed by an in sit","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T09:14:21.139Z","creation":"2025-04-04T09:14:21.139Z"},"accession":"S-EPMC9772297","cross_references":{"pubmed":["36376387"],"doi":["10.1038/s41557-022-01054-4"]}}