{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["24"],"submitter":["Liu N"],"pubmed_abstract":["Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on <i>Escherichia coli (E. coli)</i> and <i>Staphylococcus aureus (S. aureus)</i>. It could also promote the proliferation and migration of L929 fibroblasts. <i>In vivo</i> full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/"],"journal":["Bioactive materials"],"pagination":["69-80"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9772805"],"repository":["biostudies-literature"],"pubmed_title":["Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing."],"pmcid":["PMC9772805"],"pubmed_authors":["Zhao M","Zhu P","Yu C","Liu N","Xie M","Sun T","Cheng K","Chang D","Zhong Y","Guo R","Zhu S","Deng Y"],"additional_accession":[]},"is_claimable":false,"name":"Construction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing.","description":"Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on <i>Escherichia coli (E. coli)</i> and <i>Staphylococcus aureus (S. aureus)</i>. It could also promote the proliferation and migration of L929 fibroblasts. <i>In vivo</i> full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jun","modification":"2025-04-04T14:10:32.133Z","creation":"2025-04-04T14:10:32.133Z"},"accession":"S-EPMC9772805","cross_references":{"pubmed":["36582352"],"doi":["10.1016/j.bioactmat.2022.12.009"]}}