biostudies-literatureUnknown24Liu NDamaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on <i>Escherichia coli (E. coli)</i> and <i>Staphylococcus aureus (S. aureus)</i>. It could also promote the proliferation and migration of L929 fibroblasts. <i>In vivo</i> full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/Bioactive materials69-80https://www.ebi.ac.uk/biostudies/studies/S-EPMC9772805biostudies-literatureConstruction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing.PMC9772805Zhao MZhu PYu CLiu NXie MSun TCheng KChang DZhong YGuo RZhu SDeng YfalseConstruction of multifunctional hydrogel with metal-polyphenol capsules for infected full-thickness skin wound healing.Damaged skin cannot prevent harmful bacteria from invading tissues, causing infected wounds or even severe tissue damage. In this study, we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate (Cu-EGCG) nano-capsules. The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on <i>Escherichia coli (E. coli)</i> and <i>Staphylococcus aureus (S. aureus)</i>. It could also promote the proliferation and migration of L929 fibroblasts. <i>In vivo</i> full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect. Accelerate collagen deposition and wound healing speed were also observed in the SilMA/2023-01-01T00:00:00Z2023 Jun2025-04-04T14:10:32.133Z2025-04-04T14:10:32.133ZS-EPMC97728053658235210.1016/j.bioactmat.2022.12.009