{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Girard TJ"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NCI NIH HHS"],"pagination":["629-638"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9773443"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["21(3)"],"pubmed_abstract":["<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with excessive coagulation, thrombosis, and mortality.<h4>Objective</h4>To provide insight into mechanisms that contribute to excessive coagulation in coronavirus 2019 (COVID-19) disease.<h4>Patients/methods</h4>Blood from COVID-19 patients was investigated for coagulation-related gene expression and functional activities.<h4>Results</h4>Single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells from severe COVID-19 patients revealed a 5.2-fold increase in tissue factor (TF [F3 gene]) transcript expression levels (P < .05), the trigger of extrinsic coagulation; a 7.7-fold increase in C1-inhibitor (SERPING1 gene; P < .01) transcript expression levels, an inhibitor of int"],"journal":["Journal of thrombosis and haemostasis : JTH"],"pubmed_title":["Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease."],"pmcid":["PMC9773443"],"funding_grant_id":["P30 CA091842","UL1 TR002345","R01 HL120728","R61 HL141794","R37 AI049653"],"pubmed_authors":["Randolph GJ","Di Paola J","Antunes L","Steed AL","Girard TJ","Eldem I","Erlich EC","Zhang N","Mazer M","Cruchaga C","Remy KE","Subramanian R","Amrute JM"],"additional_accession":[]},"is_claimable":false,"name":"Peripheral blood mononuclear cell tissue factor (F3 gene) transcript levels and circulating extracellular vesicles are elevated in severe coronavirus 2019 (COVID-19) disease.","description":"<h4>Background</h4>Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with excessive coagulation, thrombosis, and mortality.<h4>Objective</h4>To provide insight into mechanisms that contribute to excessive coagulation in coronavirus 2019 (COVID-19) disease.<h4>Patients/methods</h4>Blood from COVID-19 patients was investigated for coagulation-related gene expression and functional activities.<h4>Results</h4>Single-cell RNA sequencing (scRNA-seq) of peripheral blood mononuclear cells from severe COVID-19 patients revealed a 5.2-fold increase in tissue factor (TF [F3 gene]) transcript expression levels (P < .05), the trigger of extrinsic coagulation; a 7.7-fold increase in C1-inhibitor (SERPING1 gene; P < .01) transcript expression levels, an inhibitor of int","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Mar","modification":"2026-05-28T19:00:37.262Z","creation":"2025-02-19T00:14:00.445Z"},"accession":"S-EPMC9773443","cross_references":{"pubmed":["36696180"],"doi":["10.1016/j.jtha.2022.11.033"]}}