biostudies-literatureUnknown22(1)Mostaza JMFerrer Internacional SA<h4>Background</h4>Cardiovascular (CV) polypills are a useful baseline treatment to prevent CV diseases by combining different drug classes in a single pill to simultaneously target more than one risk factor. The aim of the present trial was to determine whether the treatment with the CNIC-polypill was at least non-inferior to usual care in terms of low-density lipoprotein cholesterol (LDL-c) and systolic BP (SBP) values in subjects at high or very high risk without a previous CV event.<h4>Methods</h4>The VULCANO was an international, multicentre open-label trial involving 492 participants recruited from hospital clinics or primary care centres. Patients were randomised to the CNIC-polypill -containing aspirin, atorvastatin, and ramipril- or usual care. The primary outcome was the comparisBMC cardiovascular disorders560https://www.ebi.ac.uk/biostudies/studies/S-EPMC9773517biostudies-literatureSafety and efficacy of a cardiovascular polypill in people at high and very high risk without a previous cardiovascular event: the international VULCANO randomised clinical trial.PMC9773517Carrasco Franco FJCalderon Sandubete EVULCANO investigatorsCastiella Herrero JAlvarez Sala LGuijarro CCuixart Costa LSuarez Tembra MGarcia Vallejo OPedro-Botet Montoya JCJansen Chaparro SAraujo FCunha VSobrino JSantos CBorrayo GAlvarez Sanchez CMurcia Zaragoza JMAbellan Aleman JEspinosa JMoura JColoma Bazan EPose ABonilla Rovira FCabezon Mariscal JDe la Pena Fernandez AMarques Da Silva POrozco Beltran DSuarez Fernandez CCiveira FMasana Marin LCastellano Vazquez JMMostaza JMRovira Daudi EPerez PBrotons CEscobar Jimenez LCosin-Sales JArroyo Diaz JABianchi Llave JLCuenca Acevedo RGomez-Huelgas RMartinez-Hervas Alonso MATamarit JJAlfonso Megido JAraujo FPCubo Romano MPRico Corral MADiaz Diaz JLRuiz EValdivieso Felices PDiaz Rodriguez ASuarez-Fernandez CRosas Peralta MMostaza Prieto JMfalseSafety and efficacy of a cardiovascular polypill in people at high and very high risk without a previous cardiovascular event: the international VULCANO randomised clinical trial.<h4>Background</h4>Cardiovascular (CV) polypills are a useful baseline treatment to prevent CV diseases by combining different drug classes in a single pill to simultaneously target more than one risk factor. The aim of the present trial was to determine whether the treatment with the CNIC-polypill was at least non-inferior to usual care in terms of low-density lipoprotein cholesterol (LDL-c) and systolic BP (SBP) values in subjects at high or very high risk without a previous CV event.<h4>Methods</h4>The VULCANO was an international, multicentre open-label trial involving 492 participants recruited from hospital clinics or primary care centres. Patients were randomised to the CNIC-polypill -containing aspirin, atorvastatin, and ramipril- or usual care. The primary outcome was the comparis2022-01-01T00:00:00Z2022 Dec2026-05-28T21:28:28.182Z2025-04-19T22:46:22.363ZS-EPMC97735173655042410.1186/s12872-022-03013-w