biostudies-literatureUnknown12Aerts R<h4>Introduction</h4>Serum Mucorales PCR can precede the final diagnosis of invasive mucormycosis by several days or weeks and could therefore be useful as a non-invasive screening tool.<h4>Methods</h4>We assessed the performance of a commercial Mucorales PCR assay (MucorGenius®, PathoNostics, Maastricht, The Netherlands) on prospectively collected banked sera from hematology patients at risk for invasive mould infections. We evaluated if there is an underestimated incidence of missed Mucorales co-infections in patients with invasive aspergillosis (IA). We tested Mucorales PCR on the sera of all patients with a diagnosis of at least possible IA (EORTC-MSGERC consensus criteria) before the start of any antifungal therapy, and in a control group of similar high-risk hematology patients withoFrontiers in cellular and infection microbiology1080921https://www.ebi.ac.uk/biostudies/studies/S-EPMC9774025biostudies-literatureBlood Mucorales PCR to track down <i>Aspergillus</i> and Mucorales co-infections in at-risk hematology patients: A case-control study.PMC9774025Schauwvlieghe ALagrou KAerts RBevers SBeuselinck KMaertens JfalseBlood Mucorales PCR to track down <i>Aspergillus</i> and Mucorales co-infections in at-risk hematology patients: A case-control study.<h4>Introduction</h4>Serum Mucorales PCR can precede the final diagnosis of invasive mucormycosis by several days or weeks and could therefore be useful as a non-invasive screening tool.<h4>Methods</h4>We assessed the performance of a commercial Mucorales PCR assay (MucorGenius®, PathoNostics, Maastricht, The Netherlands) on prospectively collected banked sera from hematology patients at risk for invasive mould infections. We evaluated if there is an underestimated incidence of missed Mucorales co-infections in patients with invasive aspergillosis (IA). We tested Mucorales PCR on the sera of all patients with a diagnosis of at least possible IA (EORTC-MSGERC consensus criteria) before the start of any antifungal therapy, and in a control group of similar high-risk hematology patients witho2022-01-01T00:00:00Z20222026-07-14T17:37:09.799Z2025-04-05T21:04:52.705ZS-EPMC97740253656919410.3389/fcimb.2022.1080921