{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duan W"],"funding":["National Institute of Environmental Health Sciences","Center for Health Effects of Environmental Contamination, University of Iowa","NIEHS NIH HHS"],"pagination":["47341-47348"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9774403"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(50)"],"pubmed_abstract":["Estrogens and estrogen-mimicking compounds in the aquatic environment are known to cause negative impacts to both ecosystems and human health. In this initial proof-of-principle study, we developed a novel vertically oriented silicon nanowire (vSiNW) array-based biosensor for low-cost, highly sensitive and selective detection of estrogens. The vSiNW arrays were formed using an inexpensive and scalable metal-assisted chemical etching (MACE) process. A vSiNW array-based p-n junction diode (vSiNW-diode) transducer design for the biosensor was used and functionalized via 3-aminopropyltriethoxysilane (APTES)-based silane chemistry to bond estrogen receptor-alpha (ER-α) to the surface of the vSiNWs. Following receptor conjugation, the biosensors were exposed to increasing concentrations of estra"],"journal":["ACS omega"],"pubmed_title":["Sensitive and Specific Detection of Estrogens Featuring Doped Silicon Nanowire Arrays."],"pmcid":["PMC9774403"],"funding_grant_id":["P30 ES005605"],"pubmed_authors":["Gao B","Toor F","LeFevre GH","Zhi H","Keefe DW","Duan W"],"additional_accession":[]},"is_claimable":false,"name":"Sensitive and Specific Detection of Estrogens Featuring Doped Silicon Nanowire Arrays.","description":"Estrogens and estrogen-mimicking compounds in the aquatic environment are known to cause negative impacts to both ecosystems and human health. In this initial proof-of-principle study, we developed a novel vertically oriented silicon nanowire (vSiNW) array-based biosensor for low-cost, highly sensitive and selective detection of estrogens. The vSiNW arrays were formed using an inexpensive and scalable metal-assisted chemical etching (MACE) process. A vSiNW array-based p-n junction diode (vSiNW-diode) transducer design for the biosensor was used and functionalized via 3-aminopropyltriethoxysilane (APTES)-based silane chemistry to bond estrogen receptor-alpha (ER-α) to the surface of the vSiNWs. Following receptor conjugation, the biosensors were exposed to increasing concentrations of estra","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T21:54:50.079Z","creation":"2025-04-04T21:54:50.079Z"},"accession":"S-EPMC9774403","cross_references":{"pubmed":["36570182"],"doi":["10.1021/acsomega.1c00210"]}}