{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(12)"],"submitter":["Shakhov AS"],"pubmed_abstract":["Actin cytoskeleton is an essential component of living cells and plays a decisive role in many cellular processes. In mammals, β- and γ-actin are cytoplasmic actin isoforms in non-muscle cells. Despite minor differences in the amino acid sequence, β- and γ-actin localize in different cell structures and perform different functions. While cytoplasmic β-actin is involved in many intracellular processes including cell contraction, γ-actin is responsible for cell mobility and promotes tumor transformation. Numerous studies demonstrate that β- and γ-actin are spatially separated in the cytoplasm of fibroblasts and epithelial cells; this separation is functionally determined. The spatial location of β/γ-actin in endothelial cells is still a subject for discussion. Using super-resolution microsco"],"journal":["Biomedicines"],"pagination":["3194"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9775052"],"repository":["biostudies-literature"],"pubmed_title":["Colocalization Analysis of Cytoplasmic Actin Isoforms Distribution in Endothelial Cells."],"pmcid":["PMC9775052"],"pubmed_authors":["Churkina AS","Shakhov AS","Kireev II","Kovaleva PA","Alieva IB"],"additional_accession":[]},"is_claimable":false,"name":"Colocalization Analysis of Cytoplasmic Actin Isoforms Distribution in Endothelial Cells.","description":"Actin cytoskeleton is an essential component of living cells and plays a decisive role in many cellular processes. In mammals, β- and γ-actin are cytoplasmic actin isoforms in non-muscle cells. Despite minor differences in the amino acid sequence, β- and γ-actin localize in different cell structures and perform different functions. While cytoplasmic β-actin is involved in many intracellular processes including cell contraction, γ-actin is responsible for cell mobility and promotes tumor transformation. Numerous studies demonstrate that β- and γ-actin are spatially separated in the cytoplasm of fibroblasts and epithelial cells; this separation is functionally determined. The spatial location of β/γ-actin in endothelial cells is still a subject for discussion. Using super-resolution microsco","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-07T04:47:01.879Z","creation":"2025-04-07T04:47:01.879Z"},"accession":"S-EPMC9775052","cross_references":{"pubmed":["36551950"],"doi":["10.3390/biomedicines10123194"]}}