biostudies-literatureFischer DNIH Director’s OfficeNIH National Institute of Neurological Disorders and StrokeNICHD NIH HHSTiny Blue Dot FoundationNINDS NIH HHSJames S. McDonnell Foundation1710https://www.ebi.ac.uk/biostudies/studies/S-EPMC9775283biostudies-literatureUnknown12(12)Functional magnetic resonance imaging (fMRI) has shown elevations in the blood-oxygen-level-dependent (BOLD) signal associated with, but insensitive for, seizure. Rather than evaluating absolute BOLD signal elevations, assessing rhythmic oscillations in the BOLD signal with fMRI may improve the accuracy of seizure mapping. We report a case of a patient with non-convulsive, right hemispheric seizures who underwent fMRI. Unbiased processing methods revealed a map of rhythmically oscillating BOLD signal over the cortical region affected by seizure, and synchronous BOLD signal in the contralateral cerebellum. High-resolution fMRI may help identify the spatial topography of seizure and provide insights into seizure physiology.Brain sciencesIctal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations.PMC9775283DP2HD101400R21NS109627R25NS06574309R25 NS065743DP2 HD101400R21 NS109627Fischer DRapalino OEdlow BLFecchio MfalseIctal fMRI: Mapping Seizure Topography with Rhythmic BOLD Oscillations.Functional magnetic resonance imaging (fMRI) has shown elevations in the blood-oxygen-level-dependent (BOLD) signal associated with, but insensitive for, seizure. Rather than evaluating absolute BOLD signal elevations, assessing rhythmic oscillations in the BOLD signal with fMRI may improve the accuracy of seizure mapping. We report a case of a patient with non-convulsive, right hemispheric seizures who underwent fMRI. Unbiased processing methods revealed a map of rhythmically oscillating BOLD signal over the cortical region affected by seizure, and synchronous BOLD signal in the contralateral cerebellum. High-resolution fMRI may help identify the spatial topography of seizure and provide insights into seizure physiology.2022-01-01T00:00:00Z2022 Dec2024-10-16T04:04:35.345Z2024-10-16T04:04:35.345ZS-EPMC97752833655216910.3390/brainsci12121710