biostudies-literatureRamos-Solis NNCI NIH HHS3072https://www.ebi.ac.uk/biostudies/studies/S-EPMC9775318biostudies-literatureUnknown10(12)Hormonally upregulated neu-associated kinase (HUNK) is a serine/threonine (S/T) protein kinase related to the adenosine monophosphate-activated protein kinase (AMPK) family of kinases. HUNK was originally discovered using a screen to identify kinases expressed in the mouse mammary gland. Therefore, the majority of studies to date have been carried out in models specific to this tissue, and the kinase was named to reflect its mammary gland-specific physiology and pathology. Prior studies show a clear pathogenic role for HUNK in breast cancer. HUNK is upregulated in response to oncogenic HER2/neu and Akt, and there is strong evidence that HUNK is critical for the survival of breast cancer cells. Further evidence shows that inhibiting HUNK using a variety of breast cancer models, including thBiomedicinesHUNK Gene Alterations in Breast Cancer.PMC9775318R03-CA245774Dilday TRamos-Solis NKritikos AEYeh ESfalseHUNK Gene Alterations in Breast Cancer.Hormonally upregulated neu-associated kinase (HUNK) is a serine/threonine (S/T) protein kinase related to the adenosine monophosphate-activated protein kinase (AMPK) family of kinases. HUNK was originally discovered using a screen to identify kinases expressed in the mouse mammary gland. Therefore, the majority of studies to date have been carried out in models specific to this tissue, and the kinase was named to reflect its mammary gland-specific physiology and pathology. Prior studies show a clear pathogenic role for HUNK in breast cancer. HUNK is upregulated in response to oncogenic HER2/neu and Akt, and there is strong evidence that HUNK is critical for the survival of breast cancer cells. Further evidence shows that inhibiting HUNK using a variety of breast cancer models, including th2022-01-01T00:00:00Z2022 Nov2025-04-04T13:48:46.828Z2025-04-04T13:48:46.828ZS-EPMC97753183655182810.3390/biomedicines10123072