{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bicka M"],"funding":["National Science Centre","European Social Fund Project NCBiR"],"pagination":["4048"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9776847"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(24)"],"pubmed_abstract":["Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules-nine peripheral doublets and two central singlets (9 × 2 + 2). Microtubules also serve as docking sites for periodically distributed multiprotein ciliary complexes. Radial spokes, the T-shaped ciliary complexes, repeat along the outer doublets as triplets and transduce the regulatory signals from the cilium center to the outer doublet-docked dynein arms. Using the genetic, proteomic, and microscopic approaches, we have shown that lack of <i>Tetrahymena</i> Cfap91 protein affects stable docking/positioning of the radial spoke RS3 and the base of RS2, and adjacent inner dynein arms, possibly due to the abil"],"journal":["Cells"],"pubmed_title":["Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in <i>Tetrahymena</i> Cilia."],"pmcid":["PMC9776847"],"funding_grant_id":["PBS3/A8/36/2015","OPUS15 2018/29/B/NZ3/02443","OPUS13 2017/25/B/NZ3/01609"],"pubmed_authors":["Urbanska P","Konopka A","Bicka M","Osinka A","Bulska E","Wloga D","Joachimiak E"],"additional_accession":[]},"is_claimable":false,"name":"Cfap91-Dependent Stability of the RS2 and RS3 Base Proteins and Adjacent Inner Dynein Arms in <i>Tetrahymena</i> Cilia.","description":"Motile cilia and eukaryotic flagella are specific cell protrusions that are conserved from protists to humans. They are supported by a skeleton composed of uniquely organized microtubules-nine peripheral doublets and two central singlets (9 × 2 + 2). Microtubules also serve as docking sites for periodically distributed multiprotein ciliary complexes. Radial spokes, the T-shaped ciliary complexes, repeat along the outer doublets as triplets and transduce the regulatory signals from the cilium center to the outer doublet-docked dynein arms. Using the genetic, proteomic, and microscopic approaches, we have shown that lack of <i>Tetrahymena</i> Cfap91 protein affects stable docking/positioning of the radial spoke RS3 and the base of RS2, and adjacent inner dynein arms, possibly due to the abil","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-04-08T18:26:02.781Z","creation":"2025-04-04T14:52:02.209Z"},"accession":"S-EPMC9776847","cross_references":{"pubmed":["36552811"],"doi":["10.3390/cells11244048"]}}