{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu L"],"funding":["China Agriculture Research System","SAAS Program for Excellent Research Team 2022"],"pagination":["4133"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9776975"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(24)"],"pubmed_abstract":["<i>Lactobacillus</i> spp., as probiotics, have shown efficacy in alleviating nonalcoholic fatty liver disease (NAFLD). Here, we screened a new probiotic strain, <i>Lactobacillus salivarius</i> SNK-6 (<i>L. salivarius</i> SNK-6), which was isolated from the ileum of healthy Xinyang black-feather laying hens in China. We investigated the beneficial activity of <i>L. salivarius</i> SNK-6 in a NAFLD model in laying hens and found that <i>L. salivarius</i> SNK-6 inhibited liver fat deposition and decreased serum triglyceride levels and activity of aspartate transaminase and alanine transaminase. MBOAT2 (membrane-bound O-acyltransferase domain containing 2) was directly targeted by miR-130a-5p, which was downregulated in the liver of NAFLD laying hens but reversed after <i>L. salivarius</i> SNK-"],"journal":["Cells"],"pubmed_title":["<i>Lactobacillus salivarius</i> SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens."],"pmcid":["PMC9776975"],"funding_grant_id":["B-021","CARS-40-K03"],"pubmed_authors":["Yang Y","He D","Huang J","Zhu L","Liao R","Wang H","Xiao C","Yan H","Yang C"],"additional_accession":[]},"is_claimable":false,"name":"<i>Lactobacillus salivarius</i> SNK-6 Regulates Liver Lipid Metabolism Partly via the miR-130a-5p/MBOAT2 Pathway in a NAFLD Model of Laying Hens.","description":"<i>Lactobacillus</i> spp., as probiotics, have shown efficacy in alleviating nonalcoholic fatty liver disease (NAFLD). Here, we screened a new probiotic strain, <i>Lactobacillus salivarius</i> SNK-6 (<i>L. salivarius</i> SNK-6), which was isolated from the ileum of healthy Xinyang black-feather laying hens in China. We investigated the beneficial activity of <i>L. salivarius</i> SNK-6 in a NAFLD model in laying hens and found that <i>L. salivarius</i> SNK-6 inhibited liver fat deposition and decreased serum triglyceride levels and activity of aspartate transaminase and alanine transaminase. MBOAT2 (membrane-bound O-acyltransferase domain containing 2) was directly targeted by miR-130a-5p, which was downregulated in the liver of NAFLD laying hens but reversed after <i>L. salivarius</i> SNK-","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-04-08T18:27:26.206Z","creation":"2025-04-05T08:47:07.349Z"},"accession":"S-EPMC9776975","cross_references":{"pubmed":["36552896"],"doi":["10.3390/cells11244133"]}}