{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(12)"],"submitter":["Yu H"],"pubmed_abstract":["Hydroxyapatite (HAp) as natural bone composition is highly osteoinductive. To harvest its osteoinductivity in bone regenerative engineering, the HAp-supporting hydrogel is urgently needed to minimize inhomogeneous aggregation of HAp. Here, we developed a HAp-stabilizing hydrogel based on peptide self-assembly. FmocFFRR was efficient for HAp-capping due to arginine-phosphate interaction. Tethering FmocFFRR on the HAp surface facilitated self-assembly to form FmocFFRR/HAp hybrid hydrogel, enabling stable dispersion of HAp in it. The molecular interactions between FmocFFRR and HAp particles were studied using microscopic and spectral characterizations. FmocFFRR/HAp hydrogel exhibited more enhanced mechanical properties than FmocFFRR. The biocompatibility of FmocFFRR/HAp hydrogel was verified "],"journal":["Gels (Basel, Switzerland)"],"pagination":["804"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9777555"],"repository":["biostudies-literature"],"pubmed_title":["Hydroxyapatite-Tethered Peptide Hydrogel Promotes Osteogenesis."],"pmcid":["PMC9777555"],"pubmed_authors":["Li G","Jiang K","Li Y","Fan H","Zhang X","Liu S","Yu H","Song J","Zhao Y","Hao D"],"additional_accession":[]},"is_claimable":false,"name":"Hydroxyapatite-Tethered Peptide Hydrogel Promotes Osteogenesis.","description":"Hydroxyapatite (HAp) as natural bone composition is highly osteoinductive. To harvest its osteoinductivity in bone regenerative engineering, the HAp-supporting hydrogel is urgently needed to minimize inhomogeneous aggregation of HAp. Here, we developed a HAp-stabilizing hydrogel based on peptide self-assembly. FmocFFRR was efficient for HAp-capping due to arginine-phosphate interaction. Tethering FmocFFRR on the HAp surface facilitated self-assembly to form FmocFFRR/HAp hybrid hydrogel, enabling stable dispersion of HAp in it. The molecular interactions between FmocFFRR and HAp particles were studied using microscopic and spectral characterizations. FmocFFRR/HAp hydrogel exhibited more enhanced mechanical properties than FmocFFRR. The biocompatibility of FmocFFRR/HAp hydrogel was verified ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-04-04T13:49:14.356Z","creation":"2025-04-04T13:49:14.356Z"},"accession":"S-EPMC9777555","cross_references":{"pubmed":["36547328"],"doi":["10.3390/gels8120804"]}}