{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["39(12)"],"submitter":["Hansen J"],"funding":["Heinrich-Heine-Universität Düsseldorf"],"pubmed_abstract":["Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an antisolvent so that a transient emulsion is formed. Within the droplets the material can crystallize and agglomerate into spherical, hollow particles. Surfactants, such as surface-active polymers like hypromellose, are often required to stabilize the quasi-emulsion. To gain further understanding for the role of the stabilizer, a new screening-method was developed which compared different surface active polymers in solution at similar dynamic viscosities rather than at a set concentration. The dynamic visc"],"journal":["Pharmaceutical research"],"pagination":["3123-3136"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780136"],"repository":["biostudies-literature"],"pubmed_title":["Towards a better understanding of the role of stabilizers in QESD crystallizations."],"pmcid":["PMC9780136"],"pubmed_authors":["Kleinebudde P","Hansen J"],"additional_accession":[]},"is_claimable":false,"name":"Towards a better understanding of the role of stabilizers in QESD crystallizations.","description":"Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an antisolvent so that a transient emulsion is formed. Within the droplets the material can crystallize and agglomerate into spherical, hollow particles. Surfactants, such as surface-active polymers like hypromellose, are often required to stabilize the quasi-emulsion. To gain further understanding for the role of the stabilizer, a new screening-method was developed which compared different surface active polymers in solution at similar dynamic viscosities rather than at a set concentration. The dynamic visc","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-05-07T17:59:11.717Z","creation":"2025-04-04T08:44:22.273Z"},"accession":"S-EPMC9780136","cross_references":{"pubmed":["35266086"],"doi":["10.1007/s11095-022-03212-2"]}}