biostudies-literatureUnknown39(12)Hansen JHeinrich-Heine-Universität DüsseldorfQuasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an antisolvent so that a transient emulsion is formed. Within the droplets the material can crystallize and agglomerate into spherical, hollow particles. Surfactants, such as surface-active polymers like hypromellose, are often required to stabilize the quasi-emulsion. To gain further understanding for the role of the stabilizer, a new screening-method was developed which compared different surface active polymers in solution at similar dynamic viscosities rather than at a set concentration. The dynamic viscPharmaceutical research3123-3136https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780136biostudies-literatureTowards a better understanding of the role of stabilizers in QESD crystallizations.PMC9780136Kleinebudde PHansen JfalseTowards a better understanding of the role of stabilizers in QESD crystallizations.Quasi-emulsion solvent-diffusion crystallization (QESD) is a type of spherical crystallization which can be used as a particle design method to improve the flowability and micromeritic properties of drugs or excipients. Spherical particles are generated by dispersing a solvent phase in an antisolvent so that a transient emulsion is formed. Within the droplets the material can crystallize and agglomerate into spherical, hollow particles. Surfactants, such as surface-active polymers like hypromellose, are often required to stabilize the quasi-emulsion. To gain further understanding for the role of the stabilizer, a new screening-method was developed which compared different surface active polymers in solution at similar dynamic viscosities rather than at a set concentration. The dynamic visc2022-01-01T00:00:00Z2022 Dec2026-05-07T17:59:11.717Z2025-04-04T08:44:22.273ZS-EPMC97801363526608610.1007/s11095-022-03212-2