{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bradley C"],"funding":["Johns Hopkins University","National Eye Institute","NEI NIH HHS","Research to Prevent Blindness","National Institutes of Health"],"pagination":["39-47"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780153"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["130(1)"],"pubmed_abstract":["<h4>Purpose</h4>To estimate the number of OCT scans necessary to detect moderate and rapid rates of retinal nerve fiber layer (RNFL) thickness worsening at different levels of accuracy using a large sample of glaucoma and glaucoma-suspect eyes.<h4>Design</h4>Descriptive and simulation study.<h4>Participants</h4>Twelve thousand one hundred fifty eyes from 7392 adult patients with glaucoma or glaucoma-suspect status followed up at the Wilmer Eye Institute from 2013 through 2021. All eyes had at least 5 measurements of RNFL thickness on the Cirrus OCT (Carl Zeiss Meditec) with signal strength of 6 or more.<h4>Methods</h4>Rates of RNFL worsening for average RNFL thickness and for the 4 quadrants were measured using linear regression. Simulations were used to estimate the accuracy of detecting "],"journal":["Ophthalmology"],"pubmed_title":["Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening."],"pmcid":["PMC9780153"],"funding_grant_id":["5 K23 EY032204-02","K23 EY032204"],"pubmed_authors":["Ramulu P","Hou K","Unberath M","Herbert P","Yohannan J","Boland MV","Bradley C"],"additional_accession":[]},"is_claimable":false,"name":"Evidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening.","description":"<h4>Purpose</h4>To estimate the number of OCT scans necessary to detect moderate and rapid rates of retinal nerve fiber layer (RNFL) thickness worsening at different levels of accuracy using a large sample of glaucoma and glaucoma-suspect eyes.<h4>Design</h4>Descriptive and simulation study.<h4>Participants</h4>Twelve thousand one hundred fifty eyes from 7392 adult patients with glaucoma or glaucoma-suspect status followed up at the Wilmer Eye Institute from 2013 through 2021. All eyes had at least 5 measurements of RNFL thickness on the Cirrus OCT (Carl Zeiss Meditec) with signal strength of 6 or more.<h4>Methods</h4>Rates of RNFL worsening for average RNFL thickness and for the 4 quadrants were measured using linear regression. Simulations were used to estimate the accuracy of detecting ","dates":{"release":"2023-01-01T00:00:00Z","publication":"2023 Jan","modification":"2025-04-26T07:51:25.685Z","creation":"2025-04-06T12:27:49.648Z"},"accession":"S-EPMC9780153","cross_references":{"pubmed":["35932839"],"doi":["10.1016/j.ophtha.2022.07.025"]}}