biostudies-literatureBradley CJohns Hopkins UniversityNational Eye InstituteNEI NIH HHSResearch to Prevent BlindnessNational Institutes of Health39-47https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780153biostudies-literatureUnknown130(1)<h4>Purpose</h4>To estimate the number of OCT scans necessary to detect moderate and rapid rates of retinal nerve fiber layer (RNFL) thickness worsening at different levels of accuracy using a large sample of glaucoma and glaucoma-suspect eyes.<h4>Design</h4>Descriptive and simulation study.<h4>Participants</h4>Twelve thousand one hundred fifty eyes from 7392 adult patients with glaucoma or glaucoma-suspect status followed up at the Wilmer Eye Institute from 2013 through 2021. All eyes had at least 5 measurements of RNFL thickness on the Cirrus OCT (Carl Zeiss Meditec) with signal strength of 6 or more.<h4>Methods</h4>Rates of RNFL worsening for average RNFL thickness and for the 4 quadrants were measured using linear regression. Simulations were used to estimate the accuracy of detecting OphthalmologyEvidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening.PMC97801535 K23 EY032204-02K23 EY032204Ramulu PHou KUnberath MHerbert PYohannan JBoland MVBradley CfalseEvidence-Based Guidelines for the Number of Peripapillary OCT Scans Needed to Detect Glaucoma Worsening.<h4>Purpose</h4>To estimate the number of OCT scans necessary to detect moderate and rapid rates of retinal nerve fiber layer (RNFL) thickness worsening at different levels of accuracy using a large sample of glaucoma and glaucoma-suspect eyes.<h4>Design</h4>Descriptive and simulation study.<h4>Participants</h4>Twelve thousand one hundred fifty eyes from 7392 adult patients with glaucoma or glaucoma-suspect status followed up at the Wilmer Eye Institute from 2013 through 2021. All eyes had at least 5 measurements of RNFL thickness on the Cirrus OCT (Carl Zeiss Meditec) with signal strength of 6 or more.<h4>Methods</h4>Rates of RNFL worsening for average RNFL thickness and for the 4 quadrants were measured using linear regression. Simulations were used to estimate the accuracy of detecting 2023-01-01T00:00:00Z2023 Jan2025-04-26T07:51:25.685Z2025-04-06T12:27:49.648ZS-EPMC97801533593283910.1016/j.ophtha.2022.07.025