biostudies-literatureYang DNIA NIH HHSNINDS NIH HHS159-166https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780184biostudies-literatureUnknown54(1)<h4>Background</h4>Although protective in secondary stroke prevention of intracranial arterial stenosis (ICAS), it is uncertain if the benefits of leisure time physical activity (LTPA) extend to asymptomatic ICAS or extracranial carotid stenosis (ECAS). Therefore, we sought to determine LTPA's relationship with ECAS and ICAS in a stroke-free, race-ethnically diverse cohort.<h4>Methods</h4>This cross-sectional study included participants from the magnetic resonance imaging substudy of the Northern Manhattan Study, of whom 1274 had LTPA assessments at enrollment. LTPA was represented continuously as metabolic equivalent score (MET-score) and ordinally as model-based cluster analysis (LTPA-cluster), both based on the same LTPA assessments. We evaluated ECAS sonographically using carotid intimStrokePhysical Activity Is Inversely Associated With Severe Intracranial Stenosis in Stroke-Free Participants of NOMAS.PMC9780184R01 AG066162R01 NS029993R01 AG057709R37 NS029993T32 NS007153R56 NS029993Gutierrez JKhasiyev FLiu MTom SEElkind MSVCheung YKWilley JZSacco RLYang DRundek TWright CBfalsePhysical Activity Is Inversely Associated With Severe Intracranial Stenosis in Stroke-Free Participants of NOMAS.<h4>Background</h4>Although protective in secondary stroke prevention of intracranial arterial stenosis (ICAS), it is uncertain if the benefits of leisure time physical activity (LTPA) extend to asymptomatic ICAS or extracranial carotid stenosis (ECAS). Therefore, we sought to determine LTPA's relationship with ECAS and ICAS in a stroke-free, race-ethnically diverse cohort.<h4>Methods</h4>This cross-sectional study included participants from the magnetic resonance imaging substudy of the Northern Manhattan Study, of whom 1274 had LTPA assessments at enrollment. LTPA was represented continuously as metabolic equivalent score (MET-score) and ordinally as model-based cluster analysis (LTPA-cluster), both based on the same LTPA assessments. We evaluated ECAS sonographically using carotid intim2023-01-01T00:00:00Z2023 Jan2025-04-04T12:19:16.107Z2025-04-04T12:19:16.107ZS-EPMC97801843641612610.1161/STROKEAHA.122.03966010.1161/strokeaha.122.039660