{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Garty G"],"funding":["National Institute of Allergy and Infectious Diseases","NIAID NIH HHS"],"pagination":["22149"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780319"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average dose rates of up to 600 Gy/s (3.3 Gy per 0.13 µs pulse, 180 pulses per second). In this mode multiple pulses are required for most irradiations. By modulating pulse repetition rate and irradiating at SSD = 171 cm, dose rates below 1 Gy/min can be achieved, allowing comparison of FLASH and conventional irradiations with the same beam. Operating in 6 MV photon mode, with the conversion target removed (SuperFLASH mode), samples are irradiated at higher dose rates (0.2-150 Gy per 5 µs pulse, 360 pulses per second) and most irradiations can be pe"],"journal":["Scientific reports"],"pubmed_title":["Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility."],"pmcid":["PMC9780319"],"funding_grant_id":["U19 AI067773","HHSN272201600040C"],"pubmed_authors":["Royba E","Brenner DJ","Obaid R","Tan Y","Harken AD","Garty G","Deoli N"],"additional_accession":[]},"is_claimable":false,"name":"Ultra-high dose rate FLASH irradiator at the radiological research accelerator facility.","description":"The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average dose rates of up to 600 Gy/s (3.3 Gy per 0.13 µs pulse, 180 pulses per second). In this mode multiple pulses are required for most irradiations. By modulating pulse repetition rate and irradiating at SSD = 171 cm, dose rates below 1 Gy/min can be achieved, allowing comparison of FLASH and conventional irradiations with the same beam. Operating in 6 MV photon mode, with the conversion target removed (SuperFLASH mode), samples are irradiated at higher dose rates (0.2-150 Gy per 5 µs pulse, 360 pulses per second) and most irradiations can be pe","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2026-06-03T10:36:33.54Z","creation":"2025-04-04T13:48:58.222Z"},"accession":"S-EPMC9780319","cross_references":{"pubmed":["36550150"],"doi":["10.1038/s41598-022-19211-7"]}}