biostudies-literatureGarty GNational Institute of Allergy and Infectious DiseasesNIAID NIH HHS22149https://www.ebi.ac.uk/biostudies/studies/S-EPMC9780319biostudies-literatureUnknown12(1)The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average dose rates of up to 600 Gy/s (3.3 Gy per 0.13 µs pulse, 180 pulses per second). In this mode multiple pulses are required for most irradiations. By modulating pulse repetition rate and irradiating at SSD = 171 cm, dose rates below 1 Gy/min can be achieved, allowing comparison of FLASH and conventional irradiations with the same beam. Operating in 6 MV photon mode, with the conversion target removed (SuperFLASH mode), samples are irradiated at higher dose rates (0.2-150 Gy per 5 µs pulse, 360 pulses per second) and most irradiations can be peScientific reportsUltra-high dose rate FLASH irradiator at the radiological research accelerator facility.PMC9780319U19 AI067773HHSN272201600040CRoyba EBrenner DJObaid RTan YHarken ADGarty GDeoli NfalseUltra-high dose rate FLASH irradiator at the radiological research accelerator facility.The Radiological Research Accelerator Facility has modified a decommissioned Varian Clinac to deliver ultra-high dose rates: operating in 9 MeV electron mode (FLASH mode), samples can be irradiated at a Source-Surface Distance (SSD) of 20 cm at average dose rates of up to 600 Gy/s (3.3 Gy per 0.13 µs pulse, 180 pulses per second). In this mode multiple pulses are required for most irradiations. By modulating pulse repetition rate and irradiating at SSD = 171 cm, dose rates below 1 Gy/min can be achieved, allowing comparison of FLASH and conventional irradiations with the same beam. Operating in 6 MV photon mode, with the conversion target removed (SuperFLASH mode), samples are irradiated at higher dose rates (0.2-150 Gy per 5 µs pulse, 360 pulses per second) and most irradiations can be pe2022-01-01T00:00:00Z2022 Dec2026-06-03T10:36:33.54Z2025-04-04T13:48:58.222ZS-EPMC97803193655015010.1038/s41598-022-19211-7